Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters

Richard J. Robbins; Roxanne M. Landon

doi:10.1016/0006-8993(83)90866-1

Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters

Richard J. Robbins, Roxanne M. Landon

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We examine the ability of several putative amino acid neurotransmitters to influence immunoreactive somatostatin (IRS) release from cultured rat cerebral cortical cells. The cells were exposed to either single or sequential incubations in various concentrations of glutamate (Glu), aspartate (Asp), GABA, glycine, taurine and arginine. Glu and Asp were stimulatory to IRS release, whereas GABA was inhibitory. Glu-induced IRS release was calcium-dependent. Glycine and taurine were weak stimulants.

Original language	English (US)
Pages (from-to)	374-378
Number of pages	5
Journal	Brain Research
Volume	273
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90866-1
State	Published - Aug 29 1983

Keywords

amino acids
cell culture
cerebral cortex
neurotransmitters
somatostatin

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Molecular Biology
Developmental Biology

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10.1016/0006-8993(83)90866-1

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title = "Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters",

abstract = "We examine the ability of several putative amino acid neurotransmitters to influence immunoreactive somatostatin (IRS) release from cultured rat cerebral cortical cells. The cells were exposed to either single or sequential incubations in various concentrations of glutamate (Glu), aspartate (Asp), GABA, glycine, taurine and arginine. Glu and Asp were stimulatory to IRS release, whereas GABA was inhibitory. Glu-induced IRS release was calcium-dependent. Glycine and taurine were weak stimulants.",

keywords = "amino acids, cell culture, cerebral cortex, neurotransmitters, somatostatin",

author = "Robbins, {Richard J.} and Landon, {Roxanne M.}",

note = "Funding Information: Studies described in this paper were supported in part by BRSG-05357 from the Biomedical Research Grant Program, N1H and by a grant from the KROC Foundation. We would like to thank Dr. Seymour Reichlin for the somatostatin antibody, Miss Elloaise Cobb for her technical support, and Mrs. Elizabeth J. Martinez for seasoned secretarial and editorial assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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doi = "10.1016/0006-8993(83)90866-1",

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T1 - Somatostatin release from cerebral cortical cells

T2 - influence of amino acid neurotransmitters

AU - Robbins, Richard J.

AU - Landon, Roxanne M.

N1 - Funding Information: Studies described in this paper were supported in part by BRSG-05357 from the Biomedical Research Grant Program, N1H and by a grant from the KROC Foundation. We would like to thank Dr. Seymour Reichlin for the somatostatin antibody, Miss Elloaise Cobb for her technical support, and Mrs. Elizabeth J. Martinez for seasoned secretarial and editorial assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1983/8/29

Y1 - 1983/8/29

N2 - We examine the ability of several putative amino acid neurotransmitters to influence immunoreactive somatostatin (IRS) release from cultured rat cerebral cortical cells. The cells were exposed to either single or sequential incubations in various concentrations of glutamate (Glu), aspartate (Asp), GABA, glycine, taurine and arginine. Glu and Asp were stimulatory to IRS release, whereas GABA was inhibitory. Glu-induced IRS release was calcium-dependent. Glycine and taurine were weak stimulants.

AB - We examine the ability of several putative amino acid neurotransmitters to influence immunoreactive somatostatin (IRS) release from cultured rat cerebral cortical cells. The cells were exposed to either single or sequential incubations in various concentrations of glutamate (Glu), aspartate (Asp), GABA, glycine, taurine and arginine. Glu and Asp were stimulatory to IRS release, whereas GABA was inhibitory. Glu-induced IRS release was calcium-dependent. Glycine and taurine were weak stimulants.

KW - amino acids

KW - cell culture

KW - cerebral cortex

KW - neurotransmitters

KW - somatostatin

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ER -

Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters

Abstract

Keywords

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