Somatostatin release from cerebral cortical cells: influence of amino acid neurotransmitters

Richard J. Robbins, Roxanne M. Landon

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We examine the ability of several putative amino acid neurotransmitters to influence immunoreactive somatostatin (IRS) release from cultured rat cerebral cortical cells. The cells were exposed to either single or sequential incubations in various concentrations of glutamate (Glu), aspartate (Asp), GABA, glycine, taurine and arginine. Glu and Asp were stimulatory to IRS release, whereas GABA was inhibitory. Glu-induced IRS release was calcium-dependent. Glycine and taurine were weak stimulants.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalBrain Research
Volume273
Issue number2
DOIs
StatePublished - Aug 29 1983

Keywords

  • amino acids
  • cell culture
  • cerebral cortex
  • neurotransmitters
  • somatostatin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Molecular Biology
  • Developmental Biology

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