TY - JOUR
T1 - Solitary fibrous tumor of the conjunctiva with heretofore undescribed pathologic findings
AU - Kim, Na Rae
AU - Ro, Jae
AU - Shin, Kyung Hwan
AU - Paik, Hae Jung
AU - An, Jung Suk
AU - Ha, Seung Yeon
PY - 2011/6/1
Y1 - 2011/6/1
N2 - A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
AB - A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
KW - Antigens
KW - Bcl-2
KW - CD34
KW - CD99
KW - Conjunctiva
KW - Solitary fibrous tumors
UR - http://www.scopus.com/inward/record.url?scp=80052426001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052426001&partnerID=8YFLogxK
U2 - 10.4132/KoreanJPathol.2011.45.3.315
DO - 10.4132/KoreanJPathol.2011.45.3.315
M3 - Article
AN - SCOPUS:80052426001
SN - 1738-1843
VL - 45
SP - 315
EP - 318
JO - Korean Journal of Pathology
JF - Korean Journal of Pathology
IS - 3
ER -