Solitary fibrous tumor of breast with anaplastic areas (Malignant solitary fibrous tumor): A case report with review of literature

Min Jung Jung, David Alrahwan, Esther Dubrovsky, Donghwa Baek, Alberto Ayala, Jae Ro

Research output: Contribution to journalArticlepeer-review

Abstract

Solitary fibrous tumor (SFT) is a rare, soft tissue neoplasm that rarely presents in breast tissue, with only 27 previously reported cases. To our knowledge, only one case of malignant SFT has been reported in the English literature. A 75-year-old Caucasian woman presented to our institution with a 3-month history of a palpable left breast mass. No other symptoms, including nipple discharge or skin changes, were noted. She underwent 3 previous biopsies for right breast masses, all of which were benign, with no evidence of spindle cell neoplasm, atypical hyperplasia, or malignancy. Microscopic examination of the mass demonstrated a classic area of SFT with areas of high-grade anaplastic component. In these areas, the tumor showed atypical epithelioid cells arranged in hypercellular sheets with diminished branching vasculature, nuclear pleomorphism, and increased mitotic count (up to 9/10 high-power fields). This case represents the second case of malignant SFT in the breast.

Original languageEnglish (US)
Pages (from-to)326-335
Number of pages10
JournalJournal of Breast Cancer
Volume22
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • CD34
  • Dedifferentiation
  • Hemangiopericytoma
  • Malignant
  • STAT6

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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