Solid-pseudopapillary neoplasm of pancreas with long delayed liver metastasis

Pablo Gomez, Rebecca Yorke, Alberto Ayala, Jae Ro

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm that most commonly affects adolescent girls and young women. Solid-pseudopapillary neoplasm of the pancreas is considered to have malignant potential; 10% to 15% of cases are associated with metastasis, and these usually present at the time of initial diagnoses. Cases with metastases after resection are rare, and all reported cases have occurred less than 5 years after resection. We report a case of SPN in a 36-year-old woman who presented with liver metastasis 15.8 years after complete resection of the primary tumor in the pancreas. To the best of our knowledge, this is the longest time interval reported between resection of primary tumor and subsequent detection of metastatic disease. Solid-pseudopapillary neoplasm of the pancreas can present with metastases many years after resection of the primary tumor. Long-term follow-up is warranted, given the possibility of late metastasis.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalAnnals of Diagnostic Pathology
Issue number5
StatePublished - Oct 2012


  • Delayed metastasis
  • Liver
  • Pancreas
  • Solid-pseudopapillary neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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