Soft-tissue sarcomas: Detection of metabolic heterogeneity with P-31 MR spectroscopy

H. Dirk Sostman, H. Cecil Charles, Sara Rockwell, Kenneth Leopold, Craig Beam, David Madwed, Mark Dewhirst, Gary Cofer, Deborah Moore, Robert Burn, James Oleson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Regional variations in metabolic parameters derived with multivoxel, localized phosphorus-31 magnetic resonance (MR) spectroscopy in spontaneous human soft-tissue sarcomas were compared with variations in the same parameters in normal human legs. In addition, multivoxel P-31 MR spectroscopy of transplanted rodent sarcomas and microelectrode measurement of pH and Po2 in several locations within them were performed, and, when appropriate, results were compared with the clinical data. Striking voxel-voxel variability in parameters derived with P-31 spectroscopy was found in tumors, with less marked variability seen in normal legs. In the rodent tumors, spatial variations also were found in pH and Po2 measured by means of microelectrodes. These data are consistent with the results of regional measurements in tumors by means of other methods and suggest that clinical MR spectroscopic studies of tumors may need to consider the variability within malignant lesions.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
Issue number3
StatePublished - Sep 1990


  • Histiocytoma, 40.376
  • Liposarcoma, 40.371
  • Magnetic resonance (MR), phosphorus studies
  • Magnetic resonance (MR), spectroscopy
  • Neoplasms, experimental
  • Neoplasms, MR studies
  • Sarcoma
  • Schwannoma, 40.379
  • Soft tissues, neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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