Soft-tissue reconstruction following extravasation of chemotherapeutic agents

S. M. Shenaq, E. H.A. Abbase, Jeffrey D. Friedman

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


The incidence of chemotherapeutic extravasation injuries ranges from 0.5% to 6%. Chronicity and an indolent course are prominent characteristics of such wounds, as are severe pain and ulceration with no tendency to spontaneous healing. Prevention is the best treatment. Aggressive surgical debridement is recommended for patients with persistent pain or ulceration. Whirlpool therapy, wet-to-dry dressing changes, and a vigorous physical therapy program are all helpful. Soft-tissue coverage can be obtained by skin grafting, delayed flaps, various local muscle or fasciocutaneous flaps, or by free tissue transfer.

Original languageEnglish (US)
Pages (from-to)825-845
Number of pages21
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - 1996

ASJC Scopus subject areas

  • Surgery
  • Oncology


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