Sofosbuvir and Simeprevir Therapy for Recurrent Hepatitis C Infection after Liver Transplantation

Saro Khemichian, Brian Lee, Jeffrey Kahn, Mazen Noureddin, Brian Kim, Tammy Harper, Yvonne Esmailian, Tse Ling Fong

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Introduction. Antiviral therapy for recurrent hepatitis C in liver transplant recipients has been associated with low efficacy, poor tolerability, and drug-drug interactions. Recent approval of various hepatitis C direct-acting antivirals has resulted in improvement of these parameters. We evaluated the efficacy and safety of 12 week all-oral interferon- and ribavirin-free therapy with sofosbuvir and simeprevir. Methods. Thirty-two genotype 1 liver transplant recipients with recurrent hepatitis C infection were retrospectively analyzed. All patients received 12 weeks of sofosbuvir 400 mg and simeprevir 150 mg orally daily. The primary endpoint was sustained virologic response 12 weeks after treatment. Results. Sustained virologic response 12 weeks after treatment was achieved in 30 of 32 (94%; 95% confidence interval, 79-99%) patients. All patients enjoyed on-treatment virological response. Both patients who relapsed were cirrhotic, previously treated with Q80K polymorphism. Significant improvements in alkaline phosphatase, albumin, alanine aminotransferase levels, and platelets were seen at 12-week post therapy. Treatment was well tolerated. No grade 3 or 4 adverse events were noted. Headache and fatigue were the most common complaints. Conclusion. Combination of sofosbuvir and simeprevir for 12 weeks resulted in 94% sustained virological response-12 rates in patients with hepatitis C genotype 1 and was well tolerated.

Original languageEnglish (US)
Article numbere21
JournalTransplantation Direct
Volume1
Issue number6
DOIs
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Transplantation

Fingerprint

Dive into the research topics of 'Sofosbuvir and Simeprevir Therapy for Recurrent Hepatitis C Infection after Liver Transplantation'. Together they form a unique fingerprint.

Cite this