Social Vulnerability and Cardiovascular-Related Mortality Among Older Adults in the United States

Abdul Mannan Khan Minhas, Ofer Kobo, Mamas A. Mamas, Sadeer G. Al-Kindi, Layla A. Abushamat, Vijay Nambi, Erin D. Michos, Christie Ballantyne, Dmitry Abramov

Research output: Contribution to journalArticlepeer-review


Purpose: The association of social vulnerability and cardiovascular disease-related mortality in older adults has not been well characterized. Methods: The Centers for Disease Control and Prevention database was evaluated to examine the relationship between county-level Social Vulnerability Index (SVI) and age-adjusted cardiovascular disease-related mortality rates (AAMRs) in adults aged 65 and above in the United States between 2016 and 2020. Results: A total of 3139 counties in the United States were analyzed. Cardiovascular disease-related AAMRs increased in a stepwise manner from first (least vulnerable) to fourth SVI quartiles; (AAMR of 2423, 95% CI [confidence interval] 2417-2428; 2433, 95% CI 2429-2437; 2516, 95% CI 2513-2520; 2660, 95% CI 2657-2664). Similar trends among AAMRs were noted based on sex, all race and ethnicity categories, and among urban and rural regions. Higher AAMR ratios between the highest and lowest SVI quartiles, implying greater relative associations of SVI on mortality rates, were seen among Hispanic individuals (1.52, 95% CI 1.49-1.55), Non-Hispanic-Asian and Pacific Islander individuals (1.32, 95% CI 1.29-1.52), Non-Hispanic- American Indian or Alaskan Native individuals (1.43, 95% CI 1.37-1.50), and rural counties (1.21, 95% CI 1.20-1.21). Conclusion: Social vulnerability as measures by the SVI was associated with cardiovascular disease-related mortality in older adults, with the association being particularly prominent in ethnic minority patients and rural counties.

Original languageEnglish (US)
Pages (from-to)122-127.e1
JournalAmerican Journal of Medicine
Issue number2
StatePublished - Feb 2024


  • Cardiovascular disease
  • Mortality
  • Racial Disparities
  • Social Vulnerability

ASJC Scopus subject areas

  • Medicine(all)


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