Smoking is associated with advanced coronary atherosclerosis in youth

Arthur W. Zieske; C. Alex McMahan; Henry C. McGill; Satoki Homma; Hidehiro Takei; Gray T. Malcom; Richard E. Tracy; Jack P. Strong

doi:10.1016/j.atherosclerosis.2004.10.039

Smoking is associated with advanced coronary atherosclerosis in youth

Arthur W. Zieske, C. Alex McMahan, Henry C. McGill, Satoki Homma, Hidehiro Takei, Gray T. Malcom, Richard E. Tracy, Jack P. Strong

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Smoking is linked to atherosclerosis and coronary heart disease (CHD) in older adults. However, evidence that smoking affects coronary atherosclerosis in young people is incomplete. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study collected arteries, blood, and other tissues from persons 15 to 34 years of age dying of external causes and autopsied in forensic laboratories. Lesions in the proximal left anterior descending coronary arteries (LAD) from 1127 subjects were graded microscopically according to the American Heart Association criteria. Among individuals with advanced lesions (Grade 4 or 5), smokers had a greater prevalence of Grade 5 lesions than non-smokers (odds ratio 9.61, 95% confidence interval 2.34-39.57), a difference suggesting that smoking accelerates the transition from Grade 4 to Grade 5 lesions. This association occurred among both men and women, and among persons with and without other CHD risk factors. The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque.

Original language	English (US)
Pages (from-to)	87-92
Number of pages	6
Journal	Atherosclerosis
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2004.10.039
State	Published - May 2005

Keywords

Atherosclerosis
Coronary artery disease
Risk factors
Smoking
Youth

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2004.10.039

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title = "Smoking is associated with advanced coronary atherosclerosis in youth",

abstract = "Smoking is linked to atherosclerosis and coronary heart disease (CHD) in older adults. However, evidence that smoking affects coronary atherosclerosis in young people is incomplete. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study collected arteries, blood, and other tissues from persons 15 to 34 years of age dying of external causes and autopsied in forensic laboratories. Lesions in the proximal left anterior descending coronary arteries (LAD) from 1127 subjects were graded microscopically according to the American Heart Association criteria. Among individuals with advanced lesions (Grade 4 or 5), smokers had a greater prevalence of Grade 5 lesions than non-smokers (odds ratio 9.61, 95% confidence interval 2.34-39.57), a difference suggesting that smoking accelerates the transition from Grade 4 to Grade 5 lesions. This association occurred among both men and women, and among persons with and without other CHD risk factors. The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque.",

keywords = "Atherosclerosis, Coronary artery disease, Risk factors, Smoking, Youth",

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note = "Funding Information: Institutions cooperating in the PDAY study and supporting grants from the National Heart, Lung, and Blood Institute and other sources: Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.atherosclerosis.2004.10.039",

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AU - Takei, Hidehiro

AU - Malcom, Gray T.

AU - Tracy, Richard E.

AU - Strong, Jack P.

N1 - Funding Information: Institutions cooperating in the PDAY study and supporting grants from the National Heart, Lung, and Blood Institute and other sources: Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

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N2 - Smoking is linked to atherosclerosis and coronary heart disease (CHD) in older adults. However, evidence that smoking affects coronary atherosclerosis in young people is incomplete. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study collected arteries, blood, and other tissues from persons 15 to 34 years of age dying of external causes and autopsied in forensic laboratories. Lesions in the proximal left anterior descending coronary arteries (LAD) from 1127 subjects were graded microscopically according to the American Heart Association criteria. Among individuals with advanced lesions (Grade 4 or 5), smokers had a greater prevalence of Grade 5 lesions than non-smokers (odds ratio 9.61, 95% confidence interval 2.34-39.57), a difference suggesting that smoking accelerates the transition from Grade 4 to Grade 5 lesions. This association occurred among both men and women, and among persons with and without other CHD risk factors. The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque.

AB - Smoking is linked to atherosclerosis and coronary heart disease (CHD) in older adults. However, evidence that smoking affects coronary atherosclerosis in young people is incomplete. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study collected arteries, blood, and other tissues from persons 15 to 34 years of age dying of external causes and autopsied in forensic laboratories. Lesions in the proximal left anterior descending coronary arteries (LAD) from 1127 subjects were graded microscopically according to the American Heart Association criteria. Among individuals with advanced lesions (Grade 4 or 5), smokers had a greater prevalence of Grade 5 lesions than non-smokers (odds ratio 9.61, 95% confidence interval 2.34-39.57), a difference suggesting that smoking accelerates the transition from Grade 4 to Grade 5 lesions. This association occurred among both men and women, and among persons with and without other CHD risk factors. The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque.

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Smoking is associated with advanced coronary atherosclerosis in youth

Abstract

Keywords

ASJC Scopus subject areas

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