Smart MoS2/Fe3O4 nanotheranostic for magnetically targeted photothermal therapy guided by magnetic resonance/photoacoustic imaging

Jie Yu, Wenyan Yin, Xiaopeng Zheng, Gan Tian, Xiao Zhang, Tao Bao, Xinghua Dong, Zhongliang Wang, Zhanjun Gu, Xiaoyan Ma, Yuliang Zhao

Research output: Contribution to journalArticle

159 Scopus citations

Abstract

The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

Original languageEnglish (US)
Pages (from-to)931-945
Number of pages15
JournalTheranostics
Volume5
Issue number9
DOIs
StatePublished - 2015

Keywords

  • Magnetic resonance imaging
  • Magnetic target
  • Photoacoustic tomography imaging
  • Photothermal therapy
  • Theranostic

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Fingerprint Dive into the research topics of 'Smart MoS<sub>2</sub>/Fe<sub>3</sub>O<sub>4</sub> nanotheranostic for magnetically targeted photothermal therapy guided by magnetic resonance/photoacoustic imaging'. Together they form a unique fingerprint.

Cite this