Small intestinal bacterial overgrowth (SIBO) has long been regarded as an important cause of maldigestion and malabsorption in adults, typically in the context of a disturbance in the anatomy and/or physiology of the gastrointestinal tract. SIBO is less well characterised in children but has been associated with a variety of gastrointestinal and even systemic symptoms in several clinical contexts. Certain clinical situations predispose to SIBO in children, including gastric acid hyposecretion, impaired small bowel anatomy, intestinal resection and obstruction, as well as immune dysfunction. More vexed is the proposed association between SIBO and functional gastrointestinal disorders. Associations between SIBO and clinical syndromes are complicated by the challenges that its definition presents. Currently available methodologies suffer from problems with reproducibility and inadequate validation, and an accurate test for the definition of SIBO is needed. It is to be hoped that ever-evolving molecular microbiological techniques will ultimately solve this dilemma. Current treatment remains largely based on the empirical use of antibiotics given that an underlying cause can neither be identified nor corrected in the majority of those afflicted with SIBO.

Original languageEnglish (US)
Title of host publicationTextbook of Pediatric Gastroenterology, Hepatology and Nutrition
Subtitle of host publicationA Comprehensive Guide to Practice: Second Edition
PublisherSpringer International Publishing
Number of pages18
ISBN (Electronic)9783030800680
ISBN (Print)9783030800673
StatePublished - Jan 1 2021


  • Abdominal pain
  • Celiac disease
  • Cystic fibrosis
  • Diarrhoea
  • Gut microbiome
  • Gut microbiota
  • Hydrogen breath tests
  • Intestinal failure
  • Irritable bowel syndrome
  • Rifaximin
  • SIBO
  • Scleroderma
  • Small bowel aspirate
  • Small intestinal bacterial overgrowth

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Small Intestinal Bacterial Overgrowth'. Together they form a unique fingerprint.

Cite this