Small engine, big power: MicrorNAS as regulators of cardiac diseases and regeneration

Darukeshwara Joladarashi, Rajarajan Amirthalingam Thandavarayan, Sahana Suresh Babu, Prasanna Krishnamurthy

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiological conditions. miRNAs alter target expression by post-transcriptional regulation of gene expression. Numerous studies have implicated specific miRNAs in cardiovascular development, pathology, regeneration and repair. These observations suggest that miRNAs are potential therapeutic targets to prevent or treat cardiovascular diseases. This review focuses on the emerging role of miRNAs in cardiac development, pathogenesis of cardiovascular diseases, cardiac regeneration and stem cell-mediated cardiac repair. We also discuss the novel diagnostic and therapeutic potential of these miRNAs and their targets in patients with cardiac diseases.

Original languageEnglish (US)
Pages (from-to)15891-15911
Number of pages21
JournalInternational journal of molecular sciences
Volume15
Issue number9
DOIs
StatePublished - Sep 9 2014

Keywords

  • Arrhythmia
  • Cardiac development
  • Cardiac regeneration
  • Cardiovascular diseases
  • Fibrosis
  • Hypertrophy
  • Stem cells
  • miRNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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