Small animal optical diffusion tomography with targeted fluorescence

Vaibhav Gaind, Hsiao Rho Tsai, Kevin J. Webb, Venkatesh Chelvam, Philip S. Low

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Despite the broad impact in medicine that optics can bring, thus far practical approaches are limited to weak scatter or near-surface monitoring. We show a method that utilizes a laser topography scan and a diffusion equation model to describe the photon transport, together with a multiresolution unstructured grid solution to the nonlinear optimization measurement functional, that overcomes these limitations. We conclude that it is possible to achieve whole body optical imaging with a resolution suitable for finding cancer nodules within an organ during surgery, with the aid of a targeted imaging agent.

Original languageEnglish (US)
Pages (from-to)1146-1154
Number of pages9
JournalJournal of the Optical Society of America A: Optics and Image Science, and Vision
Issue number6
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Computer Vision and Pattern Recognition


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