Sleep disorders in spinocerebellar ataxia type 10

Ester London, Carlos H.F. Camargo, Alessandra Zanatta, Ana C. Crippa, Salmo Raskin, Renato P. Munhoz, Tetsuo Ashizawa, Hélio A.G. Teive

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

As sleep disturbances have been reported in spinocerebellar ataxias (SCAs), including types SCA1, SCA2, SCA3, SCA6 and SCA13, identification and management of these disturbances can help minimise their impact on SCA patients' overall body functions and quality of life. To our knowledge, there are no studies that investigate sleep disturbances in SCA10. Therefore, the aim of this study was to assess sleep disturbances in patients with SCA10. Twenty-three SCA10 patients and 23 healthy controls were recruited. Patients were evaluated in terms of their demographic and clinical data, including disease severity (Scale for the Assessment and Rating of Ataxia, SARA) and excessive daytime sleepiness (Epworth Sleepiness Scale, ESS), and underwent polysomnography. SCA10 patients had longer rapid eye movement (REM) sleep (p =.04) and more REM arousals than controls (p<.0001). There was a correlation of REM sleep onset with the age of onset of symptoms (r =.459), and with disease duration (r = −.4305). There also was correlation between the respiratory disturbance index (RDI) and SARA (r = −.4013), and a strong indirect correlation between arousal index and age at onset of symptoms (r = −.5756). In conclusion, SCA10 patients had sleep abnormalities that included more REM arousals and higher RDI than controls. Our SCA10 patients had sleep disorders related to shorter disease duration and lower severity of ataxia, in a pattern similar to that of other neurodegenerative diseases.

Original languageEnglish (US)
Article numbere12688
JournalJournal of Sleep Research
Volume27
Issue number5
DOIs
StatePublished - Oct 2018

Keywords

  • SCA10
  • arousal index
  • rapid eye movement sleep disorders
  • respiratory disturbances

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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