Sleep, autonomic dysfunction and irritable bowel syndrome (IBS)

Minjeong Christine Kwon, Eamonn Martin Quigley

Research output: Chapter in Book/Report/Conference proceedingChapter


Before addressing specific data on sleep in IBS a general introduction to this disorder is appropriate; indeed it will readily become clear that many aspects of IBS provide a context in which sleep disturbance becomes likely and even inevitable. This discussion will focus on the connection between sleep fragmentation and the bidirectional communication pathway between the “big” brain in the cranium and the “little” brain in the gut that is considered central to our understanding of IBS. The associated pathophysiologic effects on intestinal permeability, immune activation, and neurohormal and neurosensory balance are discussed.

Original languageEnglish (US)
Title of host publicationSleep Effect on Gastrointestinal Health and Disease
Subtitle of host publicationTranslational Opportunities for Promoting Health and Optimizing Disease Management
PublisherNova Science Publishers, Inc.
Number of pages17
ISBN (Electronic)9781536133608
ISBN (Print)9781536133592
StatePublished - Jan 1 2018


  • Autonomic dysfunction
  • Irritable bowel syndrome
  • Sleep disorder

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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