TY - JOUR
T1 - Sleep and breathing⋯ and cancer?
AU - Owens, Robert L.
AU - Gold, Kathryn A.
AU - Gozal, David
AU - Peppard, Paul E.
AU - Jun, Jonathan C.
AU - Lippman, Scott M.
AU - Malhotra, Atul
AU - Bazhenov, Maxim
AU - Bazhenova, Lyudmila
AU - Crotty-Alexander, Laura E.
AU - Dannenberg, Andrew J.
AU - Dubinett, Steven M.
AU - Fuster, Mark M.
AU - Gutkind, J. Silvio
AU - Montgrain, Philippe
AU - Nair, Viswam S.
AU - Onaitis, Mark W.
AU - Powis, Garth
AU - Polotsky, Vsevolod Y.
AU - Sarmiento, Kathleen F.
AU - Spira, Avrum
AU - Tamayo, Pablo
N1 - Funding Information:
Dr. A. Malhotra is PI on NIH RO1 HL085188 and K24 HL132105, and coinvestigator on R21 HL121794, RO1 HL 119201, and RO1 HL081823. As an Officer of the American Thoracic Society, Dr. A. Malhotra has relinquished all outside personal income since 2012. ResMed, Inc., provided a philanthropic donation to the UC San Diego in support of a sleep center.
Publisher Copyright:
© 2016 American Association for Cancer Research.
PY - 2016/11
Y1 - 2016/11
N2 - Sleep, like eating and breathing, is an essential part of the daily life cycle. Although the science is still emerging, sleep plays an important role in immune, cardiovascular, and neurocognitive function. Despite its great importance, nearly 40% of U.S. adults experience problems with sleep ranging from insufficient total sleep time, trouble initiating or maintaining sleep (Insomnia), circadian rhythm disorders, sleep-related movement disorders, and sleep-related breathing disorders such as obstructive sleep apnea (OSA). Herein, we discuss new evidence that suggests that sleep may also affect carcinogenesis. Specifically, we review recent epidemiologic data suggesting links between cancer and OSA. As OSA is a common, underdiagnosed, and undertreated condition, this has public health implications. Intriguing animal model data support a link between cancer and sleep/OSA, although mechanisms are not yet clear. Leaders in the fields of sleep medicine, pulmonology, and oncology recently met to review and discuss these data, as well as to outline future directions of study. We propose a multidisciplinary, three-pronged approach to studying the associations between cancer and sleep, utilizing mutually interactive epidemiologic studies, preclinical models, and earlyphase clinical trials.
AB - Sleep, like eating and breathing, is an essential part of the daily life cycle. Although the science is still emerging, sleep plays an important role in immune, cardiovascular, and neurocognitive function. Despite its great importance, nearly 40% of U.S. adults experience problems with sleep ranging from insufficient total sleep time, trouble initiating or maintaining sleep (Insomnia), circadian rhythm disorders, sleep-related movement disorders, and sleep-related breathing disorders such as obstructive sleep apnea (OSA). Herein, we discuss new evidence that suggests that sleep may also affect carcinogenesis. Specifically, we review recent epidemiologic data suggesting links between cancer and OSA. As OSA is a common, underdiagnosed, and undertreated condition, this has public health implications. Intriguing animal model data support a link between cancer and sleep/OSA, although mechanisms are not yet clear. Leaders in the fields of sleep medicine, pulmonology, and oncology recently met to review and discuss these data, as well as to outline future directions of study. We propose a multidisciplinary, three-pronged approach to studying the associations between cancer and sleep, utilizing mutually interactive epidemiologic studies, preclinical models, and earlyphase clinical trials.
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U2 - 10.1158/1940-6207.CAPR-16-0092
DO - 10.1158/1940-6207.CAPR-16-0092
M3 - Review article
C2 - 27604751
AN - SCOPUS:84994706809
VL - 9
SP - 821
EP - 827
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 11
ER -