Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

V. L. Hegde, P. A. Mahesh, Y. P. Venkatesh

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Summary: The association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa). We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin. Among patients with a history of food allergy to tomato fruit, the association was more pronounced (66%). Tomato profilin appears to be an important cross-sensitizing panallergen in respiratory allergic patients in the Indian subcontinent.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalEuropean Annals of Allergy and Clinical Immunology
Volume50
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Cross-sensitization
  • Grass pollen
  • Profilin
  • Respiratory allergy
  • Tomato

ASJC Scopus subject areas

  • Immunology and Allergy

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