Abstract
Summary: The association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa). We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin. Among patients with a history of food allergy to tomato fruit, the association was more pronounced (66%). Tomato profilin appears to be an important cross-sensitizing panallergen in respiratory allergic patients in the Indian subcontinent.
Original language | English (US) |
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Pages (from-to) | 10-18 |
Number of pages | 9 |
Journal | European Annals of Allergy and Clinical Immunology |
Volume | 50 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2018 |
Keywords
- Cross-sensitization
- Grass pollen
- Profilin
- Respiratory allergy
- Tomato
ASJC Scopus subject areas
- Immunology and Allergy