Skeletal myogenic potential of human and mouse neural stem cells

Rossella Galli, Ugo Borello, Angela Gritti, M. Giulia Minasi, Christopher Bjornson, Marcello Coletta, Marina Mora, M. Gabriella Cusella De Angelis, Roberta Fiocco, Giulio Cossu, Angelo L. Vescovi

Research output: Contribution to journalArticlepeer-review

423 Scopus citations


Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally originate from a different germ layer. Here we show that acutely isolated and clonally derived neural stem cells from mice and humans could produce skeletal myotubes in vitro and in vivo, the latter following transplantation into adult animals. Myogenic conversion in vitro required direct exposure to myoblasts, and was blocked if neural cells were clustered. Thus, a community effect between neural cells may override such myogenic induction. We conclude that neural stem cells, which generate neurons, glia and blood cells, can also produce skeletal muscle cells, and can undergo various patterns of differentiation depending on exposure to appropriate epigenetic signals in mature tissues.

Original languageEnglish (US)
Pages (from-to)986-991
Number of pages6
JournalNature Neuroscience
Issue number10
StatePublished - Oct 2000

ASJC Scopus subject areas

  • Neuroscience(all)


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