TY - JOUR
T1 - Size Matters for Interplicata Diameter
T2 - A Case-Control Study of Plateau Iris
AU - Garza, Philip S.
AU - Man, Xiaofei
AU - Queen, Joanna H.
AU - Ayres, Bernadete M.
AU - McClendon, Tanya
AU - Parrish, Elizabeth A.
AU - Reed, David M.
AU - Moroi, Sayoko E.
N1 - Funding Information:
Supported in part by the National Eye Institute, National Institutes of Health, Bethesda, Maryland (Core Center for Vision Research grant no.: EY007003); Research to Prevent Blindness, Inc., New York, New York (unrestricted grant to the University of Michigan); the National Science Foundation, Alexandria, Virginia (grant no.: AWD010114 [S.E.M.]); and the National Institutes of Health, Bethesda, Maryland (grant nos.: R01 EY022124 and R21EY03063 [S.E.M.]). The sponsors or funding organizations had no role in the design or conduct of this research. Financial Disclosure(s): The author(s) have made the following disclosure(s): S.E.M.: Financial support — Aerie Pharmaceuticals, Allergan, iCare USA, Ocuphire; Royalties — Walters Kluwer Health Obtained funding: Moroi; Study was performed as part of the authors' regular employment duties. No additional funding was provided.
Publisher Copyright:
© 2020 American Academy of Ophthalmology
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Purpose: Ultrasound biomicroscopy (UBM) has been used to characterize anterior segment dimensions in plateau iris configuration (PIC), but transverse measurements between the recesses of the ciliary sulcus (sulcus-to-sulcus diameter [STSD]) and the ciliary body processes (interplicata diameter [IPD]) have not been reported. We measured STSD and IPD and compared these among eyes with PIC, primary angle closure (PAC), and control eyes with open angles. Design: Retrospective, cross-sectional clinical study. Participants: Sixty-nine participants, 37 PIC, 13 PAC, and 19 controls. Methods: We searched our clinical UBM database for PAC and PIC cases. Controls were assembled by reviewing images obtained for surveillance of ocular surface lesions. Anterior segment measurements were performed using the UBM digital caliper tool. Robust-fit ANOVA identified among-group differences. Pairwise t tests were used to test the significance of between-group differences. Main Outcome Measures: Anterior chamber depth (ACD), angle opening distance (AOD), ciliary body area and thickness, iris area, horizontal and vertical STSD, and horizontal and vertical IPD. Results: Fifty-five left eyes were analyzed (30 PIC, 10 PAC, and 15 controls). ACD was smaller in PAC than in PIC and control eyes (P < 0.05 for PIC vs. PAC; P < 0.01 for control vs. PAC). Mean AOD was smaller in PIC than controls (P < 0.05) and smaller in PAC than PIC (P < 0.001). Vertical STSD was smaller in both PAC and PIC than controls (P = 0.04 for PIC vs. control; P < 0.01 for PAC vs. control). Horizontal STSD was smaller in PIC than controls (P = 0.02). Vertical IPD was smaller in PIC than controls (P = 0.04) and smaller in PAC than PIC eyes (P = 0.02). Horizontal IPD was smaller in PIC and PAC than controls (P = 0.03 for PIC vs. control; P < 0.01 for PAC vs. control). Conclusions: STSD and IPD are narrower in PIC and PAC than in healthy eyes. Further studies that examine the ratio of white-to-white cornea diameter to the IPD may provide a mechanism for reported cases of in-the-bag uveitis–glaucoma–hyphema syndrome in PIC.
AB - Purpose: Ultrasound biomicroscopy (UBM) has been used to characterize anterior segment dimensions in plateau iris configuration (PIC), but transverse measurements between the recesses of the ciliary sulcus (sulcus-to-sulcus diameter [STSD]) and the ciliary body processes (interplicata diameter [IPD]) have not been reported. We measured STSD and IPD and compared these among eyes with PIC, primary angle closure (PAC), and control eyes with open angles. Design: Retrospective, cross-sectional clinical study. Participants: Sixty-nine participants, 37 PIC, 13 PAC, and 19 controls. Methods: We searched our clinical UBM database for PAC and PIC cases. Controls were assembled by reviewing images obtained for surveillance of ocular surface lesions. Anterior segment measurements were performed using the UBM digital caliper tool. Robust-fit ANOVA identified among-group differences. Pairwise t tests were used to test the significance of between-group differences. Main Outcome Measures: Anterior chamber depth (ACD), angle opening distance (AOD), ciliary body area and thickness, iris area, horizontal and vertical STSD, and horizontal and vertical IPD. Results: Fifty-five left eyes were analyzed (30 PIC, 10 PAC, and 15 controls). ACD was smaller in PAC than in PIC and control eyes (P < 0.05 for PIC vs. PAC; P < 0.01 for control vs. PAC). Mean AOD was smaller in PIC than controls (P < 0.05) and smaller in PAC than PIC (P < 0.001). Vertical STSD was smaller in both PAC and PIC than controls (P = 0.04 for PIC vs. control; P < 0.01 for PAC vs. control). Horizontal STSD was smaller in PIC than controls (P = 0.02). Vertical IPD was smaller in PIC than controls (P = 0.04) and smaller in PAC than PIC eyes (P = 0.02). Horizontal IPD was smaller in PIC and PAC than controls (P = 0.03 for PIC vs. control; P < 0.01 for PAC vs. control). Conclusions: STSD and IPD are narrower in PIC and PAC than in healthy eyes. Further studies that examine the ratio of white-to-white cornea diameter to the IPD may provide a mechanism for reported cases of in-the-bag uveitis–glaucoma–hyphema syndrome in PIC.
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U2 - 10.1016/j.ogla.2020.06.007
DO - 10.1016/j.ogla.2020.06.007
M3 - Article
C2 - 32771455
AN - SCOPUS:85096947367
VL - 3
SP - 475
EP - 480
JO - Ophthalmology. Glaucoma
JF - Ophthalmology. Glaucoma
SN - 2589-4196
IS - 6
ER -