Size effect on melting temperature of nanostructured drugs

X. Liu, P. Yang, Q. Jiang

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

This study was conducted to predict the size-dependent melting temperatures of nanostructured griseofulvin (C17H17ClO6) and nifedipine (C17H18N2O6) drugs in their stable states embedded in polymer matrix based on a previous model for melting temperatures of nanocrystals. It is found that when the size of the drugs drops to several nanometers, the drops of the corresponding melting temperatures are more than 10%. Available experimental evidences support the model predictions.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalMaterials Chemistry and Physics
Volume103
Issue number1
DOIs
StatePublished - May 15 2007

Keywords

  • Melting temperature
  • Nanostructured drugs
  • Size effect

ASJC Scopus subject areas

  • Materials Chemistry

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