1 Scopus citations


Purpose: To describe a unique presentation of Central Nervous System Burkitt Lymphoma. Observations: A 59-year-old male presented with new onset binocular horizontal diplopia five days after initial presentation with abdominal distension, weight loss, and night sweats. He was diagnosed with Burkitt Lymphoma with base of skull metastasis that was initially visible only on PET scan and subsequently resolved with chemotherapy. Conclusions and Importance: Burkitt Lymphoma (BL) is an aggressive type of B-cell, non-Hodgkin, lymphoma that arises due to a translocation of the MYC proto-oncogene. Although central nervous system (CNS) involvement has been described previously with BL, isolated sixth nerve palsy as the initial sign of CNS metastasis is rare. Suspicion should remain high for metastatic disease in patients presenting with acute-onset neurologic complaints even when initial imaging is negative as timely treatment can prevent poor outcomes.

Original languageEnglish (US)
Article number100565
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Dec 2019


  • Cavernous sinus syndrome
  • Horizontal diplopia
  • Metastatic burkitt lymphoma
  • Sixth nerve palsy

ASJC Scopus subject areas

  • Ophthalmology


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