Six mRNAs with different 5' ends are encoded by a single γ- glutamyltransferase gene in mouse

S. Rajagopalan, D. F. Wan, G. M. Habib, A. R. Sepulveda, M. R. McLeod, R. M. Lebovitz, Michael W. Lieberman

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The 5′ region of the mouse γ-glutamyltransferase (γGT; EC 2.3.2.2) gene has been cloned and analyzed. This analysis, combined with sequence information obtained from γGT cDNA clones, indicates that in mouse a single γGT gene codes for six different mRNAs that differ in their 5′ sequences. Analysis of steady-state levels of γGT RNA reveals different expression patterns for these RNAs in different organs. The six different 5′ sequences are widely separated within a 10-kb region and three of them show 75-86% identity with the three known rat γGT cDNAs. Although the heterogeneity of the 5′ ends of γGT RNAs may be explained in part by alternative splicing, it is likely that multiple promoters are involved in their generation.

Original languageEnglish (US)
Pages (from-to)6179-6183
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number13
DOIs
StatePublished - 1993

Keywords

  • Gene expression
  • Kidney
  • Promoter
  • Transcription

ASJC Scopus subject areas

  • General
  • Genetics

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