SIS/PDGF-B expression in benign and malignant human breast lesions

J. Ro, J. Bresser, J. Y. Ro, F. Brasfield, G. Hortobagyi, M. Blick

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Northern blots with poly(A)-selected RNAs were prepared from four primary human breast carcinomas and hybridized with a SIS/PDGF-B gene probe. High expression of a normal-sized 3.7 kb SIS/PDGF-B transcript was observed in three samples. These three carcinomas were all T3 (> 5 cm) lesions and were histologically infiltrating ductal carcinomas accompanied by moderate to marked desmoplasia. Furthermore in situ hybridization with photobiotinylated probes was performed and demonstrated that the SIS/PDGF-B expression was localized within the epithelial cells of malignant as well as benign lesions. It is possible that SIS/PDGFB expression within the epithelial cell components of nonmalignant as well as malignant breast lesions may be in part responsible for the stromal reaction.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
Issue number3
StatePublished - 1989

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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