Sinonasal undifferentiated carcinoma (SNUC): Morphoproteomic-guided treatment paradigm with clinical efficacy

Maria Ansari, Shan Guo, Samer Fakhr, Martin J. Citardi, Angel Blanco, Maria Patino, Jamie Buryanek, Robert Amato, Ron Karni, Robert E. Brown

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly malignant tumor that occurs in the nasal cavity and/or paranasal sinuses. Prognosis is poor despite multimodality treatment. Currently, there is no optimal standard of treatment, partially due to a lack of research defining the biology of such tumors. This report discusses two SNUC cases where patients received a novel chemotherapeutic approach using cisplatin, etoposide, Adriamycin (doxorubicin), metformin, and adjuvant melatonin therapies based on morphoproteomic-guidance, followed by consolidation with chemoradiation therapy. This resulted in excellent and objective tomographic and magnetic resonance imaging and clinical responses including complete responses in the induction phase utilizing morphoproteomic-guided therapies. Later, endoscopic excision of the tumor bed failed to reveal any residual tumor. Morphoproteomics helped to define the biology of these SNUC tumors and provided targets for the agents employed, creating a new treatment paradigm for such tumors. This treatment regimen poses a new effective regimen to treat SNUC.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalAnnals of clinical and laboratory science
Volume43
Issue number1
StatePublished - Mar 21 2013

Keywords

  • Morphoproteomics
  • SNUC

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Hematology
  • Medical Laboratory Technology
  • Microbiology
  • Molecular Biology
  • Clinical Biochemistry
  • Immunology

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