Single-walled carbon nanotube materials as T2-weighted MRI contrast agents

Jeyarama S. Ananta, Michael L. Matson, Annie M. Tang, Trinanjana Mandal, Stephen Lin, Kelvin Wong, Stephen T. Wong, Lon J. Wilson

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

With their unique nanoscalar properties, single-walled carbon nanotube (SWNT) materials are widely studied for various biological applications. Herein, we report the efficiency of full-length HiPco SWNTs and ultrashort SWNTs (US-tubes) as T2-weighted MRI contrast agents. Analysis has concluded that the superparamagnetic SWNT materials (especially US-tubes) are a new class of high-efficacy contrast agents having performance contributions from both the iron catalyst nanoparticles (originating from the synthesis of SWNT materials) and the carbon SWNT material itself. The superparamagnetic US-tubes with their short length (<100 nm), negligible metal content (<1% Fe (wt %)), and superior T2 relaxation efficiency (T2 ) 31.7 ms per mg SWNT at 3 T and 37 °C) are the most promising candidates for advanced applications such as molecular and cellular imaging using MRI.

Original languageEnglish (US)
Pages (from-to)19369-19372
Number of pages4
JournalJournal of Physical Chemistry C
Volume113
Issue number45
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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