TY - JOUR
T1 - Single-prolonged stress
T2 - A review of two decades of progress in a rodent model of post-traumatic stress disorder
AU - Lisieski, Michael J.
AU - Eagle, Andrew L.
AU - Conti, Alana C.
AU - Liberzon, Israel
AU - Perrine, Shane A.
N1 - Publisher Copyright:
© 2018 Lisieski, Eagle, Conti, Liberzon and Perrine.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD.
AB - Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD.
KW - Amygdala
KW - Anxiety
KW - HPA axis
KW - Hippocampus
KW - PTSD
KW - Pre-clinical models
KW - Prefrontal cortex
KW - Single prolonged stress
UR - http://www.scopus.com/inward/record.url?scp=85046994577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046994577&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2018.00196
DO - 10.3389/fpsyt.2018.00196
M3 - Review article
AN - SCOPUS:85046994577
SN - 1664-0640
VL - 9
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - MAY
M1 - 196
ER -