Simultaneous perfusion tomography and radionuclide angiography during dobutamine stress

I. Iftikhar, M. Koutelou, John J. Mahmarian, M. S. Verani

Research output: Contribution to journalArticle

19 Scopus citations


The purpose of this investigation was to evaluate the changes in left ventricular function and volumes concurrently with tomographic myocardial perfusion during dobutamine infusion. Methods: Ninety-two patients underwent first-pass radionuclide angiography using a multicrystal gamma camera and myocardial tomography after high-dose (40 μg/kg/min) dobutamine infusion and 99mTc-sestamibi administration. Results: Dobutamine increased systolic blood pressure (p < 0.0001), heart rate (p < 0.00017), left ventricular ejection fraction (p = 0.0001), cardiac output (p = 0.0001) and stroke volume (p = 0.042). The end-diastolic (p = 0.009) and end-systolic volumes (p = 0.0007) significantly decreased. Of 38 patients with cardiac catheterization, 28 had significant coronary artery disease and 10 had normal coronaries. The sensitivity and specificity for coronary artery disease detection by myocardial perfusion tomography were 78% and 90%, respectively. By radionuclide angiography, only 9 of 27 coronary artery disease patients experienced deterioration of wall motion during dobutamine (sensitivity 33%). Conclusion: Changes in myocardial perfusion are more sensitive than changes in left ventricular function for detecting coronary artery disease during dobutamine stress.

Original languageEnglish (US)
Pages (from-to)1306-1310
Number of pages5
JournalJournal of Nuclear Medicine
Issue number8
StatePublished - Aug 1 1996


  • coronary artery disease
  • dobutamine scintigraphy
  • radionuclide angiography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Simultaneous perfusion tomography and radionuclide angiography during dobutamine stress'. Together they form a unique fingerprint.

Cite this