Simultaneous Estimation of input functions: The B-SIME method

C. Jouvie, S. De Gavriloff, M. J. Santiago Ribeiro, V. Gaura, P. Rémy, P. Zanotti-Fregonara, R. Maroy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Using Positron Emission Tomography for dynamic tracer mapping requires the knowledge of the arterial plasmatic activity concentration (PTAC). The reference method to obtain it is arterial sampling, not applicable in clinical studies because invasive and dangerous. The Simultaneous Estimation (SIME) method aims to estimate simultaneously the PTAC and the organ pharmacokinetic parameters from the time-activity curve of some tissues (three or four), with or without the help of some blood samples. The improvement proposed here, the B-SIME method, uses the results of the SIME on hundreds of sets of three tissues to evaluate the PTAC. Here an application for the 18F - FDG in human brain is shown; good results for the estimation of the PTAC were obtained, specially when using one late venous blood sample, for simulated and real data.

Original languageEnglish (US)
Title of host publication2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI'11
Pages1758-1761
Number of pages4
DOIs
StatePublished - 2011
Event2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 - Chicago, IL, United States
Duration: Mar 30 2011Apr 2 2011

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
CountryUnited States
CityChicago, IL
Period3/30/114/2/11

Keywords

  • FDG
  • Positron Emission Tomography (PET)
  • arterial input function
  • minimal invasive measurement
  • modeling

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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