Simulating metabolism in escherichia coli K- 12 - A circuit-based approach

Elebeoba E. May; Richard L. Schiek

doi:10.1109/BIOCAS.2006.4600314

Simulating metabolism in escherichia coli K- 12 - A circuit-based approach

Elebeoba E. May, Richard L. Schiek

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Computational methods for describing, understanding, and manipulating biological pathways continue to be a heavily researched area [1]-[3]. Many researchers use constructs based in electrical circuit design in the modeling and analysis of biological systems [4], [5], but few draw on and exploit parallels between electrical circuits and biological circuits for simulation purposes. We develop a biological simulation framework using X _yce™, a large-scale electrical circuit simulator, that is capable of simulating the complete metabolic system of Escherichia coli K-12. Using our framework we are able to model large-scale hybrid systems as demonstrated in successful simulation of E.coli central metabolism, a system that includes metabolic and corresponding genetic regulatory networks.

Original language	English (US)
Title of host publication	IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006
Pages	85-88
Number of pages	4
DOIs	https://doi.org/10.1109/BIOCAS.2006.4600314
State	Published - 2006
Event	IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006 - London, United Kingdom Duration: Nov 29 2006 → Dec 1 2006

Publication series

Name	IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006

Other

Other	IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006
Country/Territory	United Kingdom
City	London
Period	11/29/06 → 12/1/06

ASJC Scopus subject areas

Biomedical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/BIOCAS.2006.4600314

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Simulating metabolism in escherichia coli K- 12 - A circuit-based approach. / May, Elebeoba E.; Schiek, Richard L.
IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006. 2006. p. 85-88 4600314 (IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

May, EE & Schiek, RL 2006, Simulating metabolism in escherichia coli K- 12 - A circuit-based approach. in IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006., 4600314, IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006, pp. 85-88, IEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006, London, United Kingdom, 11/29/06. https://doi.org/10.1109/BIOCAS.2006.4600314

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AB - Computational methods for describing, understanding, and manipulating biological pathways continue to be a heavily researched area [1]-[3]. Many researchers use constructs based in electrical circuit design in the modeling and analysis of biological systems [4], [5], but few draw on and exploit parallels between electrical circuits and biological circuits for simulation purposes. We develop a biological simulation framework using X yce™, a large-scale electrical circuit simulator, that is capable of simulating the complete metabolic system of Escherichia coli K-12. Using our framework we are able to model large-scale hybrid systems as demonstrated in successful simulation of E.coli central metabolism, a system that includes metabolic and corresponding genetic regulatory networks.

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Simulating metabolism in escherichia coli K- 12 - A circuit-based approach

Abstract

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