Simulating metabolism in escherichia coli K- 12 - A circuit-based approach

Elebeoba E. May, Richard L. Schiek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Computational methods for describing, understanding, and manipulating biological pathways continue to be a heavily researched area [1]-[3]. Many researchers use constructs based in electrical circuit design in the modeling and analysis of biological systems [4], [5], but few draw on and exploit parallels between electrical circuits and biological circuits for simulation purposes. We develop a biological simulation framework using X yce™, a large-scale electrical circuit simulator, that is capable of simulating the complete metabolic system of Escherichia coli K-12. Using our framework we are able to model large-scale hybrid systems as demonstrated in successful simulation of E.coli central metabolism, a system that includes metabolic and corresponding genetic regulatory networks.

Original languageEnglish (US)
Title of host publicationIEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006
Pages85-88
Number of pages4
DOIs
StatePublished - 2006
EventIEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006 - London, United Kingdom
Duration: Nov 29 2006Dec 1 2006

Publication series

NameIEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006

Other

OtherIEEE 2006 Biomedical Circuits and Systems Conference Healthcare Technology, BioCAS 2006
CountryUnited Kingdom
CityLondon
Period11/29/0612/1/06

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

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