SILK.IT project: Silk Italian Technology for industrial biomanufacturing

Silk fibroin is a natural protein that constitutes the core fibre of the silkworm cocoon. Recently, a great deal of attention is being paid to the use of the regenerated silk fibroin (RSF) solution that can be obtained by water-processing of the cocoon fibre. Indeed, thanks to its chemical and physical properties it has been shown that substrates obtained by RSF can be used as biomaterials for several biomedical and technological applications. In this context, silk fibroin could be exploited as raw material that can become a platform for eco-sustainable manufacturing. The project SILK.IT, coordinated by the CNR-ISOF, within the framework of the Flagship Project "Factory of the Future", a research programme approved by the Interministerial Committee for Economic Planning (CIPE), aims to support this assumption by developing methods and protocols to use this silk fibroin as new material for advanced biotechnologies and sustainable manufacturing. The main goal of the project is to establish and control the whole-chain underpinning the silk fibroin-based technology, and to promote its up-scaling from the laboratory to industrial scale, targeting bio-photonics for biomedical application. The recent results obtained by the project are herein reported as key building block towards proposed achievement to establish a sustainable and process-controlled silk-based bio-manufacturing of the future.