Silicon nanoparticles and microparticles

Chaofeng Mu, Haifa Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Porous silicon nanoparticles and microparticles have great potential as drug delivery carriers of a variety of therapeutic agents in chemotherapeutics, gene delivery, molecular diagnostics, and immunotherapy due to their biodegradability, biocompatibility, and unique structural properties. The in vivo toxicological properties and biosafety of porous silicon (pSi) particles highly depend on the particles’ surface properties (size and geometries), preparation processes, administration routes and dosage. Versatile composite pSi particles can be fabricated via functionalizing them with organic and/or inorganic components to satisfy the effectiveness of different in vivo therapeutic purposes such as stimuli-responsive drug release, active drug targeting, and diagnostic imaging. This chapter focuses on the fabrication and surface functionalization of pSi nanoparticles and microparticles as drug delivery vehicles, in vivo toxicological properties and biosafety, and the therapeutic and diagnostic imaging applications.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press
Pages153-183
Number of pages31
Volume39
DOIs
StatePublished - 2016

Publication series

NameMethods in Pharmacology and Toxicology
Volume39
ISSN (Print)15572153
ISSN (Electronic)19406053

Keywords

  • Biocompatibility
  • Cancer therapy
  • Drug delivery
  • Nanoparticles
  • Porous silicon

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Molecular Medicine
  • Pharmacology (medical)

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