Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation

Giulia Neri; Nicola Micale; Angela Scala; Enza Fazio; Antonino Mazzaglia; Placido G. Mineo; Monica Montesi; Silvia Panseri; Anna Tampieri; Giovanni Grassi; Anna Piperno

doi:10.1016/j.flatc.2016.10.002

Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation

Giulia Neri, Nicola Micale, Angela Scala, Enza Fazio, Antonino Mazzaglia, Placido G. Mineo, Monica Montesi, Silvia Panseri, Anna Tampieri, Giovanni Grassi, Anna Piperno

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Graphene and its multifunctional derivatives may offer passive targeting toward tumor sites and could be designed as drug delivery systems. Surface modifications of graphene materials convey specific biological activity to themselves and improve their biocompatibility. Herein we report the conjugation of Silibinin, a flavonoid employed mainly as hepatoprotective and anticancer agent, to a graphene modified nanoplatform. The cytotoxicity of the new platform has been evaluated on human mesenchymal stem cells and the anticancer effects have been studied on a human osteosarcoma cell line. Our graphene nanoplatform did not show any cytotoxicity even at high concentration (1000 μg/ml) and Silibinin grafted onto graphene maintained its antiproliferative activity.

Original language	English (US)
Pages (from-to)	34-41
Number of pages	8
Journal	FlatChem
Volume	1
DOIs	https://doi.org/10.1016/j.flatc.2016.10.002
State	Published - Jan 1 2017

Keywords

Bioconjugation
Click chemistry
Graphene
Osteosarcoma
Silibinin

ASJC Scopus subject areas

Ceramics and Composites
Electronic, Optical and Magnetic Materials
Materials Chemistry
Surfaces, Coatings and Films

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10.1016/j.flatc.2016.10.002

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title = "Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation",

abstract = "Graphene and its multifunctional derivatives may offer passive targeting toward tumor sites and could be designed as drug delivery systems. Surface modifications of graphene materials convey specific biological activity to themselves and improve their biocompatibility. Herein we report the conjugation of Silibinin, a flavonoid employed mainly as hepatoprotective and anticancer agent, to a graphene modified nanoplatform. The cytotoxicity of the new platform has been evaluated on human mesenchymal stem cells and the anticancer effects have been studied on a human osteosarcoma cell line. Our graphene nanoplatform did not show any cytotoxicity even at high concentration (1000 μg/ml) and Silibinin grafted onto graphene maintained its antiproliferative activity.",

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T1 - Silibinin-conjugated graphene nanoplatform

T2 - Synthesis, characterization and biological evaluation

AU - Neri, Giulia

AU - Micale, Nicola

AU - Scala, Angela

AU - Fazio, Enza

AU - Mazzaglia, Antonino

AU - Mineo, Placido G.

AU - Montesi, Monica

AU - Panseri, Silvia

AU - Tampieri, Anna

AU - Grassi, Giovanni

AU - Piperno, Anna

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Graphene and its multifunctional derivatives may offer passive targeting toward tumor sites and could be designed as drug delivery systems. Surface modifications of graphene materials convey specific biological activity to themselves and improve their biocompatibility. Herein we report the conjugation of Silibinin, a flavonoid employed mainly as hepatoprotective and anticancer agent, to a graphene modified nanoplatform. The cytotoxicity of the new platform has been evaluated on human mesenchymal stem cells and the anticancer effects have been studied on a human osteosarcoma cell line. Our graphene nanoplatform did not show any cytotoxicity even at high concentration (1000 μg/ml) and Silibinin grafted onto graphene maintained its antiproliferative activity.

AB - Graphene and its multifunctional derivatives may offer passive targeting toward tumor sites and could be designed as drug delivery systems. Surface modifications of graphene materials convey specific biological activity to themselves and improve their biocompatibility. Herein we report the conjugation of Silibinin, a flavonoid employed mainly as hepatoprotective and anticancer agent, to a graphene modified nanoplatform. The cytotoxicity of the new platform has been evaluated on human mesenchymal stem cells and the anticancer effects have been studied on a human osteosarcoma cell line. Our graphene nanoplatform did not show any cytotoxicity even at high concentration (1000 μg/ml) and Silibinin grafted onto graphene maintained its antiproliferative activity.

KW - Bioconjugation

KW - Click chemistry

KW - Graphene

KW - Osteosarcoma

KW - Silibinin

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Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation

Abstract

Keywords

ASJC Scopus subject areas

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