TY - JOUR
T1 - Shorter androgen receptor CAG repeat lengths associated with cryptorchidism risk among hispanic white boys
AU - Davis-Dao, Carol
AU - Koh, Chester J.
AU - Hardy, Brian E.
AU - Chang, Andy
AU - Kim, Steve S.
AU - De Filippo, Roger
AU - Hwang, Andrew
AU - Pike, Malcolm C.
AU - Carroll, Joshua D.
AU - Coetzee, Gerhard A.
AU - Vandenberg, David
AU - Siegmund, Kimberly
AU - Cortessis, Victoria K.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - Context: Cryptorchidism is the most frequent congenital malformation among males, the major established risk factor for testicular germ cell tumors, and a presumed infertility risk factor. Androgens are essential for testicular descent, and functional genetic polymorphisms in the androgen receptor gene (AR) are postulated to influence cryptorchidism risk. Objective: The aim of the study was to investigate whether the CAG repeat length polymorphism in exon 1 of the AR is associated with cryptorchidism risk. Design and Setting: We conducted a family-based genotype-risk association study employing the transmission disequilibrium test for genotypic variants transmitted on the X-chromosome at a university-affiliated regional children's hospital. Participants: We studied 127 Hispanic boys with persistent cryptorchidism and comorbidities described in detail and their biological mothers. Intervention: Genotypes defined by number of CAG repeats were measured for each member of participating son-mother pairs. Main Outcome Measure: Associations between CAG tract length genotype and cryptorchidism risk were estimated using matched-pairs logistic regression. Results: Cryptorchidism risk was significantly associated with shorter CAG repeats [CAG ≤ 19 vs. CAG ≥ 20, odds ratio (OR) = 0.44; 95% confidence interval (CI), 0.23-0.88]. This association was restricted to cryptorchidism with accompanying comorbidities, which was primarily hernia [CAG ≤19 vs. CAG ≥ 20, OR = 0.35 (95% CI, 0.16-0.78)], and was strongest for bilateral cryptorchidism [CAG ≤ 19 vs. CAG ≥ 20, OR = 0.09 (95% CI, 0.010-0.78)]. Conclusions: Androgen receptor genotypes encoding moderate functional variation may influence cryptorchidism risk, particularly among boys with bilateral nondescent or congenital hernia, and may explain in part the elevated risk of testicular seminoma experienced by ex-cryptorchid boys. Mechanistic research is warranted to examine both classical and nonclassical mechanisms through which androgens may influence risk of cryptorchidism and related conditions.
AB - Context: Cryptorchidism is the most frequent congenital malformation among males, the major established risk factor for testicular germ cell tumors, and a presumed infertility risk factor. Androgens are essential for testicular descent, and functional genetic polymorphisms in the androgen receptor gene (AR) are postulated to influence cryptorchidism risk. Objective: The aim of the study was to investigate whether the CAG repeat length polymorphism in exon 1 of the AR is associated with cryptorchidism risk. Design and Setting: We conducted a family-based genotype-risk association study employing the transmission disequilibrium test for genotypic variants transmitted on the X-chromosome at a university-affiliated regional children's hospital. Participants: We studied 127 Hispanic boys with persistent cryptorchidism and comorbidities described in detail and their biological mothers. Intervention: Genotypes defined by number of CAG repeats were measured for each member of participating son-mother pairs. Main Outcome Measure: Associations between CAG tract length genotype and cryptorchidism risk were estimated using matched-pairs logistic regression. Results: Cryptorchidism risk was significantly associated with shorter CAG repeats [CAG ≤ 19 vs. CAG ≥ 20, odds ratio (OR) = 0.44; 95% confidence interval (CI), 0.23-0.88]. This association was restricted to cryptorchidism with accompanying comorbidities, which was primarily hernia [CAG ≤19 vs. CAG ≥ 20, OR = 0.35 (95% CI, 0.16-0.78)], and was strongest for bilateral cryptorchidism [CAG ≤ 19 vs. CAG ≥ 20, OR = 0.09 (95% CI, 0.010-0.78)]. Conclusions: Androgen receptor genotypes encoding moderate functional variation may influence cryptorchidism risk, particularly among boys with bilateral nondescent or congenital hernia, and may explain in part the elevated risk of testicular seminoma experienced by ex-cryptorchid boys. Mechanistic research is warranted to examine both classical and nonclassical mechanisms through which androgens may influence risk of cryptorchidism and related conditions.
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U2 - 10.1210/jc.2011-2439
DO - 10.1210/jc.2011-2439
M3 - Article
C2 - 22188741
AN - SCOPUS:84863229265
SN - 0021-972X
VL - 97
SP - E393-E399
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -