Shift from a mixed to a lactovegetarian diet: Influence on acidic lipids in fecal water - A potential risk factor for colon cancer

U. Geltner Allinger, G. K. Johansson, J. A. Gustafsson, J. J. Rafter

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Although there have recently been reports in the literature indicating that vegetarian-type diets are protective against the development of human colon cancer, this is still far from clear. It was also recently indicated that the concentration of acidic lipids in the aqueous phase of stool constitutes a risk factor for the development of colon cancer. Thus, we examined the effect of a change from a mixed to a lactovegetarian diet on this fecal variable. The dietary change caused a decrease in the total concentration of soluble fecal fatty acids (4310 ± 3020 to 1080 ± 1040 μmol/L, p < 0.05) and deoxycholic acid (125 ± 42 to 73 ± 35 μmol/L, P < 0.05). However, there was no change in either the total bile acid concentration in (164 ± 54 to 107 ± 41 μmol/L) or the cellular toxicity of (0.94 ± 0.55 to 1.60 ± 0.63 μmol/L, relative survival) the aqueous phase of stool. Thus, the consumption of a lactovegetarian diet may reduce certain risk factors of potential significance in colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)992-996
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume50
Issue number5
DOIs
StatePublished - 1989

Keywords

  • bile acids
  • colon cancer
  • fatty acids
  • fecal water
  • lactovegetarian diet
  • membrane toxicity

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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