Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization

April H. Nguyen; William R. Miller; Cesar A. Arias

doi:10.1016/j.molmed.2019.04.011

Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization

April H. Nguyen, William R. Miller, Cesar A. Arias

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.

Original language	English (US)
Pages (from-to)	464-466
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.molmed.2019.04.011
State	Published - Jun 2019

Keywords

Enterococcus
GI colonization
VRE
antibiotic resistance
daptomycin

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

Divisions

Infectious Disease

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10.1016/j.molmed.2019.04.011

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title = "Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization",

abstract = "Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.",

keywords = "Enterococcus, GI colonization, VRE, antibiotic resistance, daptomycin",

author = "Nguyen, \{April H.\} and Miller, \{William R.\} and Arias, \{Cesar A.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = jun,

doi = "10.1016/j.molmed.2019.04.011",

language = "English (US)",

volume = "25",

pages = "464--466",

journal = "Trends in Molecular Medicine",

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}

TY - JOUR

T1 - Shape Follows Function

T2 - Gastrointestinal Signals for Enterococcal Colonization

AU - Nguyen, April H.

AU - Miller, William R.

AU - Arias, Cesar A.

PY - 2019/6

Y1 - 2019/6

N2 - Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.

AB - Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.

KW - Enterococcus

KW - GI colonization

KW - VRE

KW - antibiotic resistance

KW - daptomycin

UR - https://www.scopus.com/pages/publications/85065795996

UR - https://www.scopus.com/inward/citedby.url?scp=85065795996&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2019.04.011

DO - 10.1016/j.molmed.2019.04.011

M3 - Short survey

C2 - 31109795

AN - SCOPUS:85065795996

SN - 1471-4914

VL - 25

SP - 464

EP - 466

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 6

ER -

Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization

Abstract

Keywords

ASJC Scopus subject areas

Divisions

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