Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization

April H. Nguyen, William R. Miller, Cesar A. Arias

Research output: Contribution to journalShort surveypeer-review

Abstract

Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.

Original languageEnglish (US)
Pages (from-to)464-466
Number of pages3
JournalTrends in Molecular Medicine
Volume25
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • Enterococcus
  • GI colonization
  • VRE
  • antibiotic resistance
  • daptomycin

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization'. Together they form a unique fingerprint.

Cite this