Sex specific expression of progesterone receptor in mouse lower urinary tract

Saija Savolainen; Risto Santti; Tomi Streng; Jan Åke Gustafsson; Pirkko Härkönen; Sari Mäkelä

doi:10.1016/j.mce.2004.11.008

Sex specific expression of progesterone receptor in mouse lower urinary tract

Saija Savolainen, Risto Santti, Tomi Streng, Jan Åke Gustafsson, Pirkko Härkönen, Sari Mäkelä

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner. PR was found to be co-expressed with ERα in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERα. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain.

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	Molecular and cellular endocrinology
Volume	230
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2004.11.008
State	Published - Jan 31 2005

Keywords

Estrogen receptor null mice
Progesterone receptor
Urinary tract

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1016/j.mce.2004.11.008

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title = "Sex specific expression of progesterone receptor in mouse lower urinary tract",

abstract = "Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner. PR was found to be co-expressed with ERα in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERα. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain.",

keywords = "Estrogen receptor null mice, Progesterone receptor, Urinary tract",

author = "Saija Savolainen and Risto Santti and Tomi Streng and Gustafsson, {Jan {\AA}ke} and Pirkko H{\"a}rk{\"o}nen and Sari M{\"a}kel{\"a}",

note = "Funding Information: Mrs. Sanna Auer, Ms. Soili Jussila and Mrs. Teija Hurmerinta are acknowledged for their skilful technical assistance. This work was supported by the Drug Discovery Graduate School and the European Commission, Contract No. QLK6-CT-2000-00565. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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AU - Savolainen, Saija

AU - Santti, Risto

AU - Streng, Tomi

AU - Gustafsson, Jan Åke

AU - Härkönen, Pirkko

AU - Mäkelä, Sari

N1 - Funding Information: Mrs. Sanna Auer, Ms. Soili Jussila and Mrs. Teija Hurmerinta are acknowledged for their skilful technical assistance. This work was supported by the Drug Discovery Graduate School and the European Commission, Contract No. QLK6-CT-2000-00565. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005/1/31

Y1 - 2005/1/31

N2 - Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner. PR was found to be co-expressed with ERα in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERα. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain.

AB - Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner. PR was found to be co-expressed with ERα in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERα. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain.

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Sex specific expression of progesterone receptor in mouse lower urinary tract

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Keywords

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