Abstract
Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.
Original language | English (US) |
---|---|
Article number | 610239 |
Journal | International Journal of Endocrinology |
Volume | 2015 |
DOIs | |
State | Published - 2015 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
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In: International Journal of Endocrinology, Vol. 2015, 610239, 2015.
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial
AU - Magee, Michelle F.
AU - Tamis-Holland, Jacqueline E.
AU - Lu, Jiang
AU - Bittner, Vera A.
AU - Brooks, Maria Mori
AU - Lopes, Neuza
AU - Jacobs, Alice K.
AU - Detre, Katherine M.
AU - Kelsey, Sheryl F.
AU - Orchard, Trevor J.
AU - Thomas, Stephen B.
AU - Tyrrell, Kim Sutton
AU - Rana, Jamal S.
AU - Averbach, Frani
AU - MacGregor, Joan M.
AU - O'Neal, Scott M.
AU - Pitluga, Kathleen
AU - Sansing, Veronica
AU - Tranchine, Mary
AU - Crow, Sharon W.
AU - Bertolet, Marianne
AU - Hardison, Regina
AU - Kip, Kevin
AU - Lombardero, Manuel
AU - Janiszewski, Sue
AU - Protivnak, Darina
AU - Reiser, Sarah
AU - Barton, Stephen
AU - Guo, Ping
AU - Kushner, Yulia
AU - Martin, Jeffrey P.
AU - Kania, Christopher
AU - Kania, Michael
AU - O'Donnell, Jeffrey
AU - Maxwell, Rae Ann
AU - Frye, Robert L.
AU - Goldberg, Suzanne
AU - Rosenberg, Yves
AU - Desvigne-Nickens, Patrice
AU - Ershow, Abby
AU - Gordon, David
AU - Paltoo, Dina
AU - Jones, Teresa L Z
AU - Hueb, Whady
AU - Ramires, José
AU - Wajchenberg, Bernardo Léo
AU - Martinez, Eulogio E.
AU - Oliveira, Sergio A.
AU - Ribeiro, Expedito E.
AU - Perin, Marcos
AU - Betti, Roberto
AU - Schwartz, Leonard
AU - Steiner, George
AU - Barolet, Alan
AU - Groenewoud, Yolanda
AU - Mighton, Lisa
AU - Camelon, Kathy
AU - O'Rourke, Robert
AU - Blodgett, Janet
AU - Sako, Edward
AU - Nicastro, Judith
AU - Prescott, Robin
AU - Rihal, Charanjit
AU - Kennedy, Frank
AU - Barsness, Gregory
AU - Basu, Amanda
AU - Clavell, Alfredo
AU - Frye, Robert
AU - Holmes, David R.
AU - Lerman, Amir
AU - Mullaney, Charles
AU - Reeder, Guy
AU - Rizza, Robert
AU - Schaff, Hartzell
AU - Smith, Steven
AU - Somers, Virend
AU - Sundt, Thoralf
AU - Ting, Henry
AU - Wright, R. Scott
AU - Helgemoe, Pam
AU - Lesmeister, Diane
AU - Rolbiecki, Deborah
AU - Lepe-Montoya, Luis
AU - Escobedo, Jorge
AU - Barraza, Rafael
AU - Baleón, Rubén
AU - Campos, Arturo
AU - García, Paula
AU - Lezama, Carlos
AU - Miramontes, Carlos
AU - Ocampo, Salvador
AU - Peñafiel, Joaquí
AU - Valdespino, Aquiles
AU - Verdín, Raúl
AU - Albarrán, Hé
AU - Ayala, Fernando
AU - Chávez, Eduardo
AU - Murillo, Hé
AU - Buitrón, Luisa Virginia
AU - Rico-Verdin, Beatriz
AU - Angulo, Fabiola
AU - Adler, Dale
AU - Arthur Halle, Austin
AU - Ismail-Beigi, Faramarz
AU - Paranjape, Suvinay
AU - Mazzurco, Stacey
AU - Ridley, Karen
AU - Ramanathan, Kodangudi
AU - Solomon, Solomon
AU - Wall, Barry
AU - Weinman, Darryl
AU - Touchstone, Tammy
AU - Douglas, Lillie
AU - Bourassa, Martial
AU - Tardif, Jean Claude
AU - Chiasson, Jean Louis
AU - Andre Lavoie, Marc
AU - Rabasa-Lhoret, Rémi
AU - Langelier, Hélène
AU - Foucher, Suzy
AU - Trudel, Johanne
AU - Monrad, Scott
AU - Srinivas, Vankeepuram
AU - Zonszein, Joel
AU - Crandall, Jill
AU - Duffy, Helena
AU - Vartolomei, Eugen
AU - King, Spencer
AU - Jacobs, Carl
AU - Robertson, David
AU - Porter, Marty
AU - Eley, Melanie
AU - Nichols, Emmalee
AU - LaCorte, Jennifer
AU - Mock, Melinda
AU - Rogers, William
AU - Ovalle, Fernando
AU - Bell, David
AU - Misra, Vijay K.
AU - Hillegass, William B.
AU - Aqel, Raed
AU - Pierce, Penny
AU - Smith, Melanie
AU - Saag, Leah
AU - Vaughn, Ashley
AU - Smith, Dwight
AU - Grimes, Tiffany
AU - Rolli, Susan
AU - Hill, Roberta
AU - Dean Barrett, Beth
AU - Morehead, Clarinda
AU - Doss, Ken
AU - Davidson, Charles J.
AU - Molitch, Mark
AU - Beohar, Nirat
AU - Massaro, Elaine
AU - Goodreau, Lynne
AU - Arroyo, Fabiola
AU - Neužil, Petr
AU - Pavlíɥková, Lenka
AU - Stehlíková, Štěpánka
AU - Benedik, Jaroslav
AU - Coling, Liz
AU - Davies, Richard
AU - Glover, Christopher
AU - LeMay, Michel
AU - Mesana, Thierry
AU - Ooi, Teik Chye
AU - Silverman, Mark
AU - Sorisky, Alexander
AU - Favreau, Colette
AU - McClinton, Susan
AU - Weiss, Melvin
AU - Weiss, Irene
AU - Saulle, Leo
AU - Kannam, Harichandra
AU - Kurylas, Joanne C.
AU - Vasi, Lorraine
AU - Douglas, John
AU - Ghazzal, Ziyad
AU - Sperling, Laurence
AU - Dayamani, Priya
AU - Gebhart, Suzanne
AU - Basu, Sabreena
AU - Helmy, Tarek
AU - Tangpricha, Vin
AU - Hyde, Pamela
AU - Jenkins, Margaret
AU - Grant, Barbara P.
AU - Kent, Kenneth
AU - Suddath, William
AU - Julien-Williams, Patricia
AU - Reed, Vida
AU - Nassar, Carine
AU - Dagenais, Gilles
AU - Garceau, Claude
AU - Auger, Dominique
AU - Buller, Christopher
AU - Elliott, Tom
AU - Ramanathan, Krishnan
AU - Ricci, Donald
AU - Fox, Rebecca
AU - Kolesniak, Daniela
AU - Attubato, Michael
AU - Feit, Frederick
AU - Richardson, Stephen
AU - Sing, Ivan Pena
AU - Slater, James
AU - Amendola, Angela
AU - Vargas, Bernardo
AU - Tsapatsaris, Nicholas
AU - Woods, Bartholomew
AU - Cushing, Gary
AU - Rutter, Martin K.
AU - Singh, Premranjan
AU - DesRochers, Gail
AU - Woodhead, Gail
AU - Gannon, Deborah
AU - Campbell, Nancy Shinopulos
AU - Ragosta, Michael
AU - Sarembock, Ian
AU - Powers, Eric
AU - Barrett, Eugene
AU - Jahn, Linda
AU - Murie, Karen
AU - Das, Gladwin
AU - Sigurdsson, Gardar
AU - White, Carl
AU - Bantle, John
AU - Redmon, J. Bruce
AU - Kwong, Christine
AU - Albu, Jeanine
AU - Hochman, Judith S.
AU - Wilentz, James
AU - Frances, Sylvaine
AU - Tormey, Deborah
AU - Pepine, Carl
AU - Smith, Karen
AU - Kennedy, Laurence
AU - Brezner, Karen
AU - Curry, Tempa
AU - Bleyer, Frank
AU - Albert, Stewart
AU - Mooradian, Arshag
AU - Plummer, Sharon
AU - Fuentes, Francisco
AU - Robles, Roberto
AU - Lavis, Victor
AU - Gomez, Jaime
AU - Iliescu, Cesar
AU - Underwood, Carol
AU - Fulton, Maria Selin
AU - Ramirez, Julie Gomez
AU - Merta, Jennifer
AU - Scott, Glenna
AU - Krishnaswami, Ashok
AU - Dowdell, Lynn
AU - Berkheimer, Sarah
AU - Greenbaum, Adam
AU - Whitehouse, Fred
AU - Pangilinan, Raquel
AU - Mann, Kelly
AU - Sternthal, Elliot
AU - Ebner, Susana
AU - Nedeljkovic, Zoran
AU - Beardsley, Paula
AU - Schneider, David
AU - Pratley, Richard
AU - Cefalu, William
AU - Schnure, Joel
AU - Rowen, Michaelanne
AU - Tilton, Linda
AU - Niederman, Alan
AU - Mata, Cristina
AU - Kellerman, Terri
AU - Farmer, John
AU - Garber, Alan J.
AU - Kleiman, Neal
AU - Howard, Nancy
AU - Nichols, Debra
AU - Pool, Madonna
AU - Granger, Christopher
AU - Feinglos, Mark
AU - Adams, George
AU - Green, Jennifer
AU - Druken, Bernadette
AU - Underwood, Dani
AU - Stafford, J. Lawrence
AU - Donner, Thomas
AU - Laskey, Warren
AU - Beach, Dana
AU - Lopez, John
AU - Davis, Andrew
AU - Faxon, David
AU - Reutrakul, Sirimon
AU - Bayer, Emily
AU - Marroquin, Oscar
AU - Cohen, Howard
AU - Korytkowski, Mary
AU - Koerbel, Glory
AU - Baxendell, Lisa
AU - Rosenfelder, Debbie
AU - DeRiso, Louise
AU - Farrell, Carole
AU - Vita, Tina
AU - McGill, Janet
AU - Krone, Ronald
AU - Bach, Richard
AU - Recklein, Carol
AU - Luepke, Kristin M.
AU - Clifton, Mary Jane
AU - Farkouh, Michael E.
AU - Kim, Michael C.
AU - Smith, Donald A.
AU - Guzman, Ida
AU - Travis, Arlene
AU - O'Keefe, James
AU - Forker, Alan
AU - Isley, William
AU - Moe, Richard
AU - Kennedy, Paul
AU - Rosson, Margaret
AU - Long, Aimee
AU - Bates, Eric
AU - Herman, William
AU - Pop-Busui, Rodica
AU - Duvernoy, Claire
AU - Stevens, Martin
AU - Luciano, Ann
AU - Majors, Cheryl
AU - Gottlieb, Sheldon H.
AU - Rodriguez, Annabelle
AU - Herr, Melanie
AU - Williams, David
AU - Smith, Robert J.
AU - Bbott, Dawn J.
AU - Laufgraben, Marc J.
AU - Grogan, Mary
AU - Muratori, Janice
AU - Habib, Gabriel
AU - Marcelli, Marco
AU - Mikati, Issam
AU - Cordero, Emilia
AU - Caldwell, Gina
AU - Chechter, David
AU - Lorber, Daniel
AU - August, Phyllis
AU - Brown, Maisie
AU - Depree, Patricia
AU - Huber, Kurt
AU - Hanusch-Enserer, Ursula
AU - Jordanova, Nelly
AU - Cilesiz, Dilek
AU - Vogel, Birgit
AU - McCallister, Ben
AU - Kleerekoper, Michael
AU - Mandagere, Kelly
AU - Urbanic, Robert
AU - Bengston, James
AU - Kong, Bobby K.
AU - Pruitt, Andrew
AU - Sanfield, Jeffrey
AU - Carulli, Carol
AU - Churley-Strom, Ruth
AU - Magorien, Raymond
AU - Osei, Kwame
AU - Boyer, Cecilia Casey
AU - Lee, Richard
AU - Palumbo, Pasquale
AU - Wisbey, Joyce
AU - Alderman, Edwin
AU - Ikeno, Fumiaki
AU - Schwarzkopf, Anne
AU - Steffes, Michael
AU - Nowicki, Maren
AU - Bucksa, Jean
AU - Chaitman, Bernard
AU - Eckstein, Jane
AU - Stocke, Karen
AU - Hlatky, Mark A.
AU - Boothroyd, Derek B.
AU - Melsop, Kathryn A.
AU - Sobel, Burton E.
AU - Neimane, Dagnija
AU - Iskandrian, Ami E.
AU - Schaaf, Mary Beth
AU - Genuth, Saul
AU - Bongarno, Theresa
AU - Nesto, Richard
AU - Hultberg, Karen
AU - Rosenhouse-Romeo, Helene
AU - Pambianco, Georgia
AU - Mock, Michael
AU - Teresa, L. Z Jones
AU - Kelsey, Sheryl
AU - Orchard, Trevor
AU - Ryan, Thomas
AU - Lebovitz, Harold
AU - Brown, Robert
AU - Friesinger, Gottlieb
AU - Horton, Edward
AU - Mason, Jay
AU - Virmani, Renu
AU - Wechsler, Lawrence
AU - Bairey-Merz, C. Noel
AU - J. Ennedy, Ward
AU - Antman, Elliott
AU - Colwell, John
AU - Fowler, Sarah
AU - Furberg, Curt
AU - Goldman, Lee
AU - Jennings, Bruce
AU - Rankin, Scott
N1 - Publisher Copyright: © 2015 Michelle F. Magee et al.
PY - 2015
Y1 - 2015
N2 - Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.
AB - Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.
UR - http://www.scopus.com/inward/record.url?scp=84927601878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927601878&partnerID=8YFLogxK
U2 - 10.1155/2015/610239
DO - 10.1155/2015/610239
M3 - Article
AN - SCOPUS:84927601878
SN - 1687-8337
VL - 2015
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 610239
ER -