Sex differences in the hepatic in vitro metabolism of 4-androstene-3, 17-dione in rainbow trout, Salmo gairdnerii

Thu Hansson; Jan Åke Gustafsson

doi:10.1016/0016-6480(81)90246-X

Sex differences in the hepatic in vitro metabolism of 4-androstene-3, 17-dione in rainbow trout, Salmo gairdnerii

Thu Hansson, Jan Åke Gustafsson

Houston Methodist

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	General and Comparative Endocrinology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/0016-6480(81)90246-X
State	Published - Jun 1981

ASJC Scopus subject areas

Animal Science and Zoology
Endocrinology

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10.1016/0016-6480(81)90246-X

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title = "Sex differences in the hepatic in vitro metabolism of 4-androstene-3, 17-dione in rainbow trout, Salmo gairdnerii",

abstract = "The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.",

author = "Thu Hansson and Gustafsson, \{Jan {\AA}ke\}",

note = "Funding Information: This work was supported by grants from the Swedish Medical Research Council (13X-2819), the National Swedish Environment Protection Board (7-334-79), Adlerbertska Forskningsfonden, and Lars Hiertas Minne. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1981",

month = jun,

doi = "10.1016/0016-6480(81)90246-X",

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journal = "General and Comparative Endocrinology",

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AU - Gustafsson, Jan Åke

N1 - Funding Information: This work was supported by grants from the Swedish Medical Research Council (13X-2819), the National Swedish Environment Protection Board (7-334-79), Adlerbertska Forskningsfonden, and Lars Hiertas Minne. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1981/6

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N2 - The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.

AB - The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.

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Sex differences in the hepatic in vitro metabolism of 4-androstene-3, 17-dione in rainbow trout, Salmo gairdnerii

Abstract

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