TY - JOUR
T1 - Sex differences in the hepatic in vitro metabolism of 4-androstene-3, 17-dione in rainbow trout, Salmo gairdnerii
AU - Hansson, Thu
AU - Gustafsson, Jan Åke
N1 - Funding Information:
This work was supported by grants from the Swedish Medical Research Council (13X-2819), the National Swedish Environment Protection Board (7-334-79), Adlerbertska Forskningsfonden, and Lars Hiertas Minne.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/6
Y1 - 1981/6
N2 - The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.
AB - The metabolism of androstenedione by liver microsomes from rainbow trout, Salmo gairdnerii, at different stages of sexual development was studied, 17-Hydroxysteroid oxidoreductase activity in male trout increased significantly during the spawning period, while no such increase was seen in female trout. On the other hand, 6β-hydroxylase activity was significantly lower in maturing female trout when compared to juvenile and mature trout of both sexes. 5α-Reductase and 16-hydroxylase activities exhibited no sex-dependent variations during the period of sexual development in trout. A possible role for the liver in regulation of steroid biosynthesis in fish is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0019362827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019362827&partnerID=8YFLogxK
U2 - 10.1016/0016-6480(81)90246-X
DO - 10.1016/0016-6480(81)90246-X
M3 - Article
C2 - 6941909
AN - SCOPUS:0019362827
SN - 0016-6480
VL - 44
SP - 181
EP - 188
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 2
ER -