Sex differences in outcomes of transcatheter edge-to-edge repair with MitraClip: A meta-analysis

Lina Ya'Qoub, Mohamed Gad, Nadeen N. Faza, Katherine J. Kunkel, Rawan Ya'acoub, Pedro Villablanca, Rodrigo Bagur, Mirvat Alasnag, Marvin Eng, Islam Y. Elgendy

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Transcatheter edge-to-edge repair (TEER) with MitraClip improves outcomes among select patients with moderate–to-severe and severe mitral regurgitation; however, data regarding sex-specific differences in the outcomes among patients undergoing TEER are limited. Methods: An electronic search of the PubMed, Embase, Central, and Web of Science databases for studies comparing sex differences in outcomes among patients undergoing TEER was performed. Summary estimates were primarily conducted using a random-effects model. Results: Eleven studies with a total of 24,905 patients (45.6% women) were included. Women were older and had a lower prevalence of comorbidities, including diabetes, chronic kidney disease, and coronary artery disease. There was no difference in procedural success (odds ratio [OR]: 0.75, 95% confidence interval [CI]: 0.55–1.05) and short-term mortality (i.e., up to 30 days) between women and men (OR: 1.16, 95% CI: 0.97–1.39). Women had a higher incidence of periprocedural bleeding and stroke (OR: 1.34, 95% CI: 1.15–1.56) and (OR: 1.57, 95% CI: 1.10–2.25), respectively. At a median follow-up of 12 months, there was no difference in mortality (OR: 0.98, 95% CI: 0.89–1.09) and heart failure hospitalizations (OR: 1.07, 95% CI: 0.68–1.67). An analysis of adjusted long-term mortality showed a lower incidence of mortality among women (hazards ratio: 0.77, 95% CI: 0.67–0.88). Conclusions: Despite a lower prevalence of baseline comorbidities, women undergoing TEER with MitraClip had higher unadjusted rates of periprocedural stroke and bleeding as compared with men. There was no difference in unadjusted procedural success, short-term or long-term mortality. However, women had lower adjusted mortality on long-term follow-up. Future high-quality studies assessing sex differences in outcomes after TEER are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)1819-1828
Number of pages10
JournalCatheterization and Cardiovascular Interventions
Issue number6
StatePublished - May 1 2022


  • MitraClip
  • outcomes
  • percutaneous mitral valve repair
  • sex differences
  • transcatheter edge-to-edge mitral valve repair
  • Mitral Valve Insufficiency/diagnostic imaging
  • Humans
  • Male
  • Stroke/etiology
  • Treatment Outcome
  • Sex Characteristics
  • Mitral Valve/surgery
  • Heart Valve Prosthesis Implantation/adverse effects
  • Cardiac Catheterization/adverse effects
  • Female

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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