Sex dependent prepubertal gonadotrophin surges in the rat

P. Eneroth, J. A. Gustafsson, P. Skett, A. Stenberg

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11 Scopus citations

Abstract

The concentration of LH (luteinizing hormone) and FSH (follicle stimulating hormone) were measured by radioimmunoassay in sera from immature male and female rats of various ages. Fairly high levels of FSH were found in both sexes at birth but LH was not detected. FSH peaks appeared in the male at 13 and 19 days of age and in the female at 13 and 17 to 19 days of age. LH was undetectable in the male before 12 days of age, rose to a peak (440 ± 60 (S.D.) ng/ml) at 13 days of age and fell below the detection level again between 15 and 25 days of age. A further increase then occurred which almost reached adult levels. LH was first detectable in the female rat at 11 days of age with a peak value of 130 ± 35 ng/ml at 12 days. The hormone was undetectable on days 14 and 15, rose to a second peak on day 18 (148 ± 56 ng/ml), and was again absent between 19 and 25 days of age. The concentration rose, as in the male, between days 25 and 28 to a level similar to that of the adult. The results show sexual differences in prepubertal gonadotrophin surges. The LH peak at 12 to 13 days in both sexes appears to be light dependent. The FSH peak at this time was affected by light, but was not strictly light dependent.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalJournal of Endocrinology
Volume65
Issue number1
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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