Sex and the liver - A journey through five decades

Agneta Mode, Jan Åke Gustafsson

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Metabolism of steroids and drugs in rodents is sexually differentiated. The reason for this turned out to be the sexually differentiated growth hormone (GH) secretory pattern regulating the expression of a number of hepatic cytochrome P-450 genes. Although not fully resolved, it is clear that several signaling pathways and transcription factors are involved in mediating the effects of GH. It may be argued that such a well-controlled physiological system should have an important biological role and we speculate that the demands of a robust hepatic steroid metabolism during pregnancy has led to the development of this sexually differentiated hypothalamo-pituitary-liver axis.

Original languageEnglish (US)
Pages (from-to)197-207
Number of pages11
JournalDrug Metabolism Reviews
Volume38
Issue number1-2
DOIs
StatePublished - 2006

Keywords

  • Cytochrome P450
  • Gene Regulation
  • Growth hormone
  • Liver
  • Rat
  • Sex difference

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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