Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia

Zuo Xiang He, Thomas Hedrick, Craig Pratt, Mario S. Verani, Vincent Aquino, Robert Roberts, John J. Mahmarian

Research output: Contribution to journalArticlepeer-review

319 Scopus citations


Background - Detection of subclinical coronary artery disease (CAD) before the development of life-threatening cardiac complications has great potential clinical relevance. Electron beam computed tomography (EBCT) is currently the only noninvasive test that can detect CAD in all stages of its development and thus has the potential to be an excellent screening technique for identifying asymptomatic subjects with underlying myocardial ischemia. Methods and Results - Over 2.5 years, we prospectively studied 3895 generally asymptomatic subjects with EBCT, 411 of whom had stress myocardial perfusion tomography (SPECT) within a close (median, 17 days) time period. SPECT and exercise treadmill results were compared with the coronary artery calcium score (CACS) as assessed by EBCT. The total CACS identified a population at high risk for having myocardial ischemia by SPECT although only a minority of subjects (22%) with an abnormal EBCT had an abnormal SPECT. No subject with CACS < 10 had an abnormal SPECT compared with 2.6% of those with scores from 11 to 100, 11.3% of those with scores from 101 to 399, and 46% of those with scores ≥400 (P<0.0001). CACS predicted an abnormal SPECT regardless of subject age or sex. Conclusions - CACS identifies a high-risk group of asymptomatic subjects who have clinically important silent myocardial ischemia. Our results support the role of EBCT as the initial screening tool for identifying individuals at various stages of CAD development for whom therapeutic decision making may differ considerably.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
Issue number3
StatePublished - Jan 25 2000


  • Calcium
  • Ischemia
  • Tomography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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