Severe pre-eclampsia among pregnant women with sickle cell disease and HIV

Javon Prophet, Kalifa Kelly, Julian Domingo, Helen Ayeni, Xaviera Pascale Djoko Mekouguem, Breana Dockery, Farida Allam, Manvir Kaur, Javon Artis, Kiara K. Spooner, Jason L. Salemi, Omonike Olaleye, Hamisu M. Salihu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: The relationship between sickle cell disease (SCD) and severe pre-eclampsia is poorly established. It is also unknown whether the occurrence of HIV infection among women with SCD modifies their risk level for severe pre-eclampsia. We hypothesized that pregnant women with SCD are at an elevated risk for severe pre-eclampsia as a result of heightened endothelial damage; and the combination of SCD-HIV augments the inflammatory processes of endothelial damage leading to amplified risk for severe pre-eclampsia. Study design: We analyzed more than 57 million pregnancy-related hospitalizations and births in the US from January 1, 2002 through December 31, 2014. Main outcome measures: We applied multivariable survey logistic regression to generate odds ratios for the association between SCD, HIV and SCD-HIV status and severe pre-eclampsia with adjustment for potential confounders. Results: Of the total 57,326,459 pregnant women, 57,198,505 (99.78%) did not have SCD or HIV, 73,064 (12.7 per 10,000) had HIV only, 54,890 (9.58 per 10,000) had SCD only and 222 (0.39 per 100,000) had both SCD and HIV. Mothers with SCD and HIV-SCD experienced a significant elevation in risk for severe pre-eclampsia of about 60% (OR = 1.61; 95% CI = 1.44, 1.79) and of more than 300% (OR = 4.28; 95% CI = 1.35, 13.62) respectively. Conclusion: In the largest study on SCD and pre-eclampsia in the world, we established SCD to be strongly associated with severe pre-eclampsia. Another unique finding is the synergistic effect of amplified risk for severe pre-eclampsia among mothers with the combined SCD-HIV status.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalPregnancy Hypertension
StatePublished - Jan 2018


  • HIV
  • Pre-eclampsia
  • Pregnancy
  • Sickle cell disease
  • Severity of Illness Index
  • Multivariate Analysis
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Humans
  • Middle Aged
  • Risk Factors
  • Logistic Models
  • Pre-Eclampsia/diagnosis
  • HIV Infections/diagnosis
  • Young Adult
  • United States/epidemiology
  • Health Surveys
  • Anemia, Sickle Cell/diagnosis
  • Adolescent
  • Adult
  • Female
  • Odds Ratio
  • Databases, Factual

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Internal Medicine


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