Abstract
A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e135-e137 |
| Journal | Journal of pediatric hematology/oncology |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 6 2015 |
Keywords
- RH genotype
- alloimmunization
- delayed hemolytic transfusion reaction
- red blood cell transfusion
- sickle cell disease
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
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