Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

Tina S. Ipe, Jennifer J. Wilkes, Helge D. Hartung, Connie M. Westhoff, Stella T. Chou, David F. Friedman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

Original languageEnglish (US)
Pages (from-to)e135-e137
JournalJournal of pediatric hematology/oncology
Volume37
Issue number2
DOIs
StatePublished - Mar 6 2015

Keywords

  • RH genotype
  • alloimmunization
  • delayed hemolytic transfusion reaction
  • red blood cell transfusion
  • sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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