Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

Tina S. Ipe; Jennifer J. Wilkes; Helge D. Hartung; Connie M. Westhoff; Stella T. Chou; David F. Friedman

doi:10.1097/MPH.0000000000000241

Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

Tina S. Ipe, Jennifer J. Wilkes, Helge D. Hartung, Connie M. Westhoff, Stella T. Chou, David F. Friedman

Department of Pathology & Genomic Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

Original language	English (US)
Pages (from-to)	e135-e137
Journal	Journal of pediatric hematology/oncology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000000241
State	Published - Mar 6 2015

Keywords

RH genotype
alloimmunization
delayed hemolytic transfusion reaction
red blood cell transfusion
sickle cell disease

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/MPH.0000000000000241

Cite this

@article{92ee559f0ee843799f29a6096d3f4c3f,

title = "Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease",

abstract = "A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.",

keywords = "RH genotype, alloimmunization, delayed hemolytic transfusion reaction, red blood cell transfusion, sickle cell disease",

author = "Ipe, {Tina S.} and Wilkes, {Jennifer J.} and Hartung, {Helge D.} and Westhoff, {Connie M.} and Chou, {Stella T.} and Friedman, {David F.}",

note = "Publisher Copyright: {\textcopyright} 2014 Wolters Kluwer Health, Inc.",

year = "2015",

month = mar,

day = "6",

doi = "10.1097/MPH.0000000000000241",

language = "English (US)",

volume = "37",

pages = "e135--e137",

journal = "Journal of pediatric hematology/oncology",

issn = "1077-4114",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

AU - Ipe, Tina S.

AU - Wilkes, Jennifer J.

AU - Hartung, Helge D.

AU - Westhoff, Connie M.

AU - Chou, Stella T.

AU - Friedman, David F.

PY - 2015/3/6

Y1 - 2015/3/6

N2 - A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

AB - A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD∗DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

KW - RH genotype

KW - alloimmunization

KW - delayed hemolytic transfusion reaction

KW - red blood cell transfusion

KW - sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=84924178967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924178967&partnerID=8YFLogxK

U2 - 10.1097/MPH.0000000000000241

DO - 10.1097/MPH.0000000000000241

M3 - Article

C2 - 25171447

AN - SCOPUS:84924178967

SN - 1077-4114

VL - 37

SP - e135-e137

JO - Journal of pediatric hematology/oncology

JF - Journal of pediatric hematology/oncology

IS - 2

ER -

Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this