Severe Atypical Endometrial Changes and Sequential Contraceptive Use

Raymond H. Kaufman, Keith O. Reeves, Cary M. Dougherty

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Of eight young women, seven had a diagnosis of well-differentiated endometrial adenocarcinoma and one had atypical endometrial hyperplasia. The average age was 40.1 years, with 6.04 years of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalJournal of the American Medical Association
Issue number8
StatePublished - Aug 23 1976

ASJC Scopus subject areas

  • Medicine(all)


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