TY - JOUR
T1 - Severe Atypical Endometrial Changes and Sequential Contraceptive Use
AU - Kaufman, Raymond H.
AU - Reeves, Keith O.
AU - Dougherty, Cary M.
PY - 1976/8/23
Y1 - 1976/8/23
N2 - Of eight young women, seven had a diagnosis of well-differentiated endometrial adenocarcinoma and one had atypical endometrial hyperplasia. The average age was 40.1 years, with 6.04 years of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.
AB - Of eight young women, seven had a diagnosis of well-differentiated endometrial adenocarcinoma and one had atypical endometrial hyperplasia. The average age was 40.1 years, with 6.04 years of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.
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U2 - 10.1001/jama.1976.03270090017018
DO - 10.1001/jama.1976.03270090017018
M3 - Article
C2 - 988889
AN - SCOPUS:0017314020
VL - 236
SP - 923
EP - 926
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
SN - 0098-7484
IS - 8
ER -