Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review

Sachin S. Goel; Mobolaji Ige; E. Murat Tuzcu; Stephen G. Ellis; William J. Stewart; Lars G. Svensson; Bruce W. Lytle; Samir R. Kapadia

doi:10.1016/j.jacc.2013.01.096

Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review

Sachin S. Goel, Mobolaji Ige, E. Murat Tuzcu, Stephen G. Ellis, William J. Stewart, Lars G. Svensson, Bruce W. Lytle, Samir R. Kapadia

Research output: Contribution to journal › Review article › peer-review

222 Scopus citations

Abstract

Management of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve replacement (TAVR) is posing challenges. Due to limited and heterogeneous data on the prevalence and clinical impact of CAD on the outcomes of TAVR and the management strategies for CAD in patients undergoing TAVR, we performed a comprehensive review of the literature. Significant CAD is present in 40% to 75% of patients undergoing TAVR. The impact of CAD on outcomes after TAVR remains understudied. Based on existing data, not all patients require revascularization before TAVR. Percutaneous coronary intervention (PCI) should be considered for severely stenotic lesions in proximal coronaries that subtend a large area of myocardium at risk. Ongoing studies randomizing patients to surgical or percutaneous management strategies for severe AS will help provide valuable data regarding the impact of CAD on TAVR outcomes, the role of PCI, and its timing in relation to TAVR.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Journal of the American College of Cardiology
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.jacc.2013.01.096
State	Published - Jul 2 2013

Keywords

aortic stenosis
coronary artery disease
surgical aortic valve replacement
transcatheter aortic valve replacement

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jacc.2013.01.096

Cite this

Goel, S. S., Ige, M., Tuzcu, E. M., Ellis, S. G., Stewart, W. J., Svensson, L. G., Lytle, B. W., & Kapadia, S. R. (2013). Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review. Journal of the American College of Cardiology, 62(1), 1-10. https://doi.org/10.1016/j.jacc.2013.01.096

Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review. / Goel, Sachin S.; Ige, Mobolaji; Tuzcu, E. Murat et al.
In: Journal of the American College of Cardiology, Vol. 62, No. 1, 02.07.2013, p. 1-10.

Research output: Contribution to journal › Review article › peer-review

Goel, SS, Ige, M, Tuzcu, EM, Ellis, SG, Stewart, WJ, Svensson, LG, Lytle, BW & Kapadia, SR 2013, 'Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review', Journal of the American College of Cardiology, vol. 62, no. 1, pp. 1-10. https://doi.org/10.1016/j.jacc.2013.01.096

@article{1c9c0dbf5c6f483eaf93b32d7232149e,

title = "Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review",

abstract = "Management of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve replacement (TAVR) is posing challenges. Due to limited and heterogeneous data on the prevalence and clinical impact of CAD on the outcomes of TAVR and the management strategies for CAD in patients undergoing TAVR, we performed a comprehensive review of the literature. Significant CAD is present in 40% to 75% of patients undergoing TAVR. The impact of CAD on outcomes after TAVR remains understudied. Based on existing data, not all patients require revascularization before TAVR. Percutaneous coronary intervention (PCI) should be considered for severely stenotic lesions in proximal coronaries that subtend a large area of myocardium at risk. Ongoing studies randomizing patients to surgical or percutaneous management strategies for severe AS will help provide valuable data regarding the impact of CAD on TAVR outcomes, the role of PCI, and its timing in relation to TAVR.",

keywords = "aortic stenosis, coronary artery disease, surgical aortic valve replacement, transcatheter aortic valve replacement",

author = "Goel, {Sachin S.} and Mobolaji Ige and Tuzcu, {E. Murat} and Ellis, {Stephen G.} and Stewart, {William J.} and Svensson, {Lars G.} and Lytle, {Bruce W.} and Kapadia, {Samir R.}",

year = "2013",

month = jul,

day = "2",

doi = "10.1016/j.jacc.2013.01.096",

language = "English (US)",

volume = "62",

pages = "1--10",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era

T2 - A comprehensive review

AU - Goel, Sachin S.

AU - Ige, Mobolaji

AU - Tuzcu, E. Murat

AU - Ellis, Stephen G.

AU - Stewart, William J.

AU - Svensson, Lars G.

AU - Lytle, Bruce W.

AU - Kapadia, Samir R.

PY - 2013/7/2

Y1 - 2013/7/2

N2 - Management of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve replacement (TAVR) is posing challenges. Due to limited and heterogeneous data on the prevalence and clinical impact of CAD on the outcomes of TAVR and the management strategies for CAD in patients undergoing TAVR, we performed a comprehensive review of the literature. Significant CAD is present in 40% to 75% of patients undergoing TAVR. The impact of CAD on outcomes after TAVR remains understudied. Based on existing data, not all patients require revascularization before TAVR. Percutaneous coronary intervention (PCI) should be considered for severely stenotic lesions in proximal coronaries that subtend a large area of myocardium at risk. Ongoing studies randomizing patients to surgical or percutaneous management strategies for severe AS will help provide valuable data regarding the impact of CAD on TAVR outcomes, the role of PCI, and its timing in relation to TAVR.

AB - Management of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve replacement (TAVR) is posing challenges. Due to limited and heterogeneous data on the prevalence and clinical impact of CAD on the outcomes of TAVR and the management strategies for CAD in patients undergoing TAVR, we performed a comprehensive review of the literature. Significant CAD is present in 40% to 75% of patients undergoing TAVR. The impact of CAD on outcomes after TAVR remains understudied. Based on existing data, not all patients require revascularization before TAVR. Percutaneous coronary intervention (PCI) should be considered for severely stenotic lesions in proximal coronaries that subtend a large area of myocardium at risk. Ongoing studies randomizing patients to surgical or percutaneous management strategies for severe AS will help provide valuable data regarding the impact of CAD on TAVR outcomes, the role of PCI, and its timing in relation to TAVR.

KW - aortic stenosis

KW - coronary artery disease

KW - surgical aortic valve replacement

KW - transcatheter aortic valve replacement

UR - http://www.scopus.com/inward/record.url?scp=84879370254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879370254&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2013.01.096

DO - 10.1016/j.jacc.2013.01.096

M3 - Review article

C2 - 23644089

AN - SCOPUS:84879370254

SN - 0735-1097

VL - 62

SP - 1

EP - 10

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 1

ER -

Severe aortic stenosis and coronary artery disease - Implications for management in the transcatheter aortic valve replacement era: A comprehensive review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this