Sesquiterpenes, lignans and other constituents from Saussurea macrota

Min Yang; Chun Ming Wang; Qi Zhang; Yi Feng Han; Zhong Jian Jia

Sesquiterpenes, lignans and other constituents from Saussurea macrota

Min Yang, Chun Ming Wang, Qi Zhang, Yi Feng Han, Zhong Jian Jia

Research output: Contribution to journal › Article › peer-review

Abstract

From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

Original language	English (US)
Pages (from-to)	972-976
Number of pages	5
Journal	Pharmazie
Volume	59
Issue number	12
State	Published - Dec 2004

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Pharmaceutical Science

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Medical Oncology

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title = "Sesquiterpenes, lignans and other constituents from Saussurea macrota",

abstract = "From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.",

author = "Min Yang and Wang, \{Chun Ming\} and Qi Zhang and Han, \{Yi Feng\} and Jia, \{Zhong Jian\}",

year = "2004",

month = dec,

language = "English (US)",

volume = "59",

pages = "972--976",

journal = "Pharmazie",

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T1 - Sesquiterpenes, lignans and other constituents from Saussurea macrota

AU - Yang, Min

AU - Wang, Chun Ming

AU - Zhang, Qi

AU - Han, Yi Feng

AU - Jia, Zhong Jian

PY - 2004/12

Y1 - 2004/12

N2 - From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

AB - From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

UR - https://www.scopus.com/pages/publications/10844242131

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M3 - Article

C2 - 15638090

AN - SCOPUS:10844242131

SN - 0031-7144

VL - 59

SP - 972

EP - 976

JO - Pharmazie

JF - Pharmazie

IS - 12

ER -

Sesquiterpenes, lignans and other constituents from Saussurea macrota

Abstract

ASJC Scopus subject areas

Divisions

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